palmatine

RN given refers to parent cpd; structure

Also Known As:

berbericinine; berbinium, 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-, chloride; berbinium, 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-, iodide; dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride (1:1); dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, hydroxide (1:1); o,o-dimethyldemethyleneberberine; palmatine cation; palmatine chloride; palmatine hydrochloride; palmatine hydroxide; palmatine iodide; palmatine ion; palmatine sulfate; palmatinium hydroxide; palmitine hydroxide; 5,6-dihydro-2,3,9,10-tetramethoxydibenzo(a,g)quinolizinium

Networked: 109 relevant articles (9 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzylisoquinolines: 151
    - Berberine Alkaloids: 9
      - palmatine: 109
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Berberine Alkaloids: 9
      - palmatine: 109

Experts

1.	Li, Xuegang: 4 articles (01/2020 - 05/2015)
2.	Ye, Xiaoli: 4 articles (01/2020 - 05/2015)
3.	Su, Zi-Ren: 3 articles (01/2022 - 11/2018)
4.	Gao, Yun: 3 articles (01/2021 - 01/2018)
5.	Xiong, Wei: 3 articles (01/2021 - 01/2018)
6.	Yin, Cancan: 3 articles (01/2021 - 01/2018)
7.	Huang, Lu: 2 articles (02/2022 - 01/2020)
8.	Kukula-Koch, Wirginia: 2 articles (10/2021 - 01/2020)
9.	Ali, Huma: 2 articles (01/2021 - 01/2013)
10.	Huang, Ruoyu: 2 articles (01/2021 - 01/2020)

Related Diseases

1.	Ischemia 08/01/2009 - "Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat." 01/01/2010 - "The anti-ischemia effect in myocardium of Rhizoma Corydalis is related to the direct protective effects on cardiomyocytes of its components, tetrahydropalmatine, dehydrocorydaline, berberine and palmatine, amomg which tetrahydropalmatine and dehydrocorydaline are the most important, the former with high safety and low efficacy, while the latter with low safety and high efficacy. " 01/01/2010 - "To observe the effects of tetrahydropalmatine, dehydrocorydaline, berberine and palmatine on anoxia and peroxidation injuries in cardiomyocytes, and study the marterial basis of the anti-ischemia effect on myocardium of Rhizoma Corydalis. "
2.	Atrophic Gastritis 09/05/2020 - "Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17/EGFR." 01/01/2020 - "UPLC-Q-TOF/MS-Based Serum and Urine Metabonomics Study on the Ameliorative Effects of Palmatine on Helicobacter pylori-Induced Chronic Atrophic Gastritis."
3.	Hypoxia (Hypoxemia) 01/01/2022 - "Results: Administering palmatine 1-10 mg/kg dose dependently improved hypoxemia, ameliorated metastasis associated lung injury; histology score of 3.33 ± 0.33, 1.67 ± 0.33, 1.33 ± 0.33, decreased lung MTA1 (2.19 ± 0.12, 1.83 ± 0.04, 1.84 ± 0.05) and increased p53 expression (1.99 ± 0.06, 2.27 ± 0.12, 2.34 ± 0.12) respectively. " 01/01/2010 - "Tetrahydropalmatine, dehydrocorydaline, berberine and palmatine significantly inhibited LDH leakage induced by anoxia-reoxia injury, at concentrations of 50-100, 1.25-5, 4 and 30 mg x L(-1), respectively (P < 0.05 or P < 0.01). " 01/01/2010 - "To observe the effects of tetrahydropalmatine, dehydrocorydaline, berberine and palmatine on anoxia and peroxidation injuries in cardiomyocytes, and study the marterial basis of the anti-ischemia effect on myocardium of Rhizoma Corydalis. "
4.	Malaria 01/30/2024 - "Between berberine and palmatine isolated from the potent fractions, only the former showed ∼100% and 90% inhibitions of liver stage parasite at 5 μg/ml and 1 μg/ml, respectively, while the latter showed no inhibition even at 20 μg/ml. This study reports that the ethnomedicinal use of HHA to manage malaria can be attributed to the presence of promising antiplasmodial protoberberine alkaloids together with synergistic effects via either enhancement of bioavailability or improved pharmacokinetics by other phytoconstituent(s) coming from other HHA constituent plants. "
5.	Neoplasm Metastasis (Metastasis) 01/01/2022 - "Conclusion: Palmatine preserved lung morphology and demonstrated therapeutic potential in aiding the treatment of lung metastasis." 10/25/2023 - "Furthermore, palmatine significantly disrupted the tumor vasculature and inhibited metastasis to adjacent lymph nodes. " 01/01/2022 - "Results: Administering palmatine 1-10 mg/kg dose dependently improved hypoxemia, ameliorated metastasis associated lung injury; histology score of 3.33 ± 0.33, 1.67 ± 0.33, 1.33 ± 0.33, decreased lung MTA1 (2.19 ± 0.12, 1.83 ± 0.04, 1.84 ± 0.05) and increased p53 expression (1.99 ± 0.06, 2.27 ± 0.12, 2.34 ± 0.12) respectively. "

Related Drugs and Biologics

1.	Berberine
2.	Alkaloids
3.	protoberberine
4.	coptisine
5.	jatrorrhizine
6.	epiberberine
7.	tetrahydropalmatine
8.	dehydrocorydalin
9.	ilomastat
10.	isoquinoline

Related Therapies and Procedures

1.	Oral Administration
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Therapeutics
4.	Photochemotherapy (Photodynamic Therapy)
5.	Traditional Medicine (Folk Remedies)