phenacemide

12/01/1987 - "Seizure control was achieved at plasma drug levels that ranged from 16 to 75 micrograms/ml. The median effective dose in our series was 52 micrograms/ml. The recurrence of seizures in three patients was, in each case, associated with trough plasma phenacemide levels below 50 micrograms/dl."
07/01/1986 - "Phenacemide monotherapy controlled seizures in four children with intractable partial complex epilepsy. "
12/01/1987 - "We used monotherapy with phenacemide to treat complex partial seizures in 13 children who were refractory to conventional antiepileptic drug therapy. "
11/01/1978 - "Diphenylhydantoin, phenobarbitone, phenacemide, carbamezepine and clonazepam but not ethosuximide are effective against generalized clonic-tonic seizures, suggesting that this is a model for "grand mal" but not "petit mal" seizure mechanisms. "
10/01/1980 - "(TF, TH and CL or MCL) in an almost same antagonism, 2) drugs (phenacemide, dipropylacetate, pheneturide, acetylpheneturide and phenobarbital) which inhibit all forms of seizures at relatively dissociated doses for the prevention of each component of seizures, 3) drugs (diphenylhydantoin and carbamazepine) which selectively abolish both components (TF and TH) of tonic seizures, and 4) drugs (acetazolamide, sulthiame and primidone) exclusively blocking TH of tonic seizures. "

07/01/1986 - "The use of phenacemide for intractable partial complex epilepsy in children."
03/01/1986 - "Three adolescent patients with severe seizure disorders were treated with phenacemide. "
03/28/1957 - "Phenacemide in the treatment of epilepsy: results of treatment of 411 patients and review of the literature."
12/10/1955 - "Use of phenacemide in epilepsy, with analysis of fatal reactions and case report."
09/01/1951 - "Phenacemide in treatment of epilepsy."

12/01/1987 - "Phenacemide therapy of complex partial epilepsy in children: determination of plasma drug concentrations."
04/01/1978 - "Three patients under treatment with phenacemide for uncontrollable psychomotor epilepsy were found to have greatly increased serum creatinine levels in the absence of elevated blood urea nitrogen (BUN) values or any other evidence of renal disease. "

12/01/1987 - "Phenacemide therapy was well tolerated with a minimum of untoward side effects and no evidence of irreversible drug toxicity. "

01/01/1994 - "To report two cases of increased true serum creatinine (Scr) without renal failure caused by an anticonvulsant drug, phenacemide, and to discuss the possible mechanisms. "