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moperone

RN given refers to parent cpd; structure

Also Known As:

4'-fluoro-4-(4-hydroxy-4-4-tolylpiperidino)butyrophenone; methylperidol; moperone hydrochloride

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Butyrophenones: 43
    - moperone: 8

Related Diseases

1.	Psychotic Disorders (Schizoaffective Disorder) 01/01/1977 - "The sustained release form of butyrophenone derivative moperone hydrochloride was tested within the scope of an open clinical study including 20 patients with mostly chronic, schizophrenic psychoses. " 04/01/1971 - "[Clinical evaluation of a butyrophenone derivative, methylperidol, in 40 cases of schizophrenia and other psychoses]." 01/12/1970 - "[Controlled comparative study of methylperidol and perphenazine in schizoprenic psychoses]."
2.	Ulcer 01/01/1977 - "Pimozide, moperone, trifluperidol and chlorpromazine fail to influence the development of the experimental ulcers. "
3.	Sudden Infant Death (SID) 10/01/1993 - "Haloperidol, moperone, pipamperone and bromperidol were found measurable with high sensitivity by gas chromatography (GC) with surface ionization detection (SID). "
4.	Schizophrenia (Dementia Praecox) 04/01/1971 - "[Clinical evaluation of a butyrophenone derivative, methylperidol, in 40 cases of schizophrenia and other psychoses]."
5.	Glaucoma 01/01/1984 - "Contrary to timolol, haloperidol, moperone and trifluperidol relaxed histamine pretreated guinea pig tracheal muscle at doses as low as 0.03-1.0 microgram/ml, whereas cardiac contractility and heart rate were little suppressed at doses up to 3 micrograms/ml. Since dopamine antagonists do not block the beta-adrenergic receptors and the ophthalmic dose required to lower IOP is only a small fraction of the antipsychotic doses, it is concluded that dopamine antagonists could be used for glaucoma treatment with little noticeable side effects, if any."

Related Drugs and Biologics

1.	Trifluperidol
2.	Haloperidol (Haldol)
3.	Dopamine Antagonists
4.	Antipsychotic Agents (Antipsychotics)
5.	Timolol (Blocadren)
6.	beta Adrenergic Receptors
7.	Pimozide (Orap)
8.	Perphenazine (Trilafon)
9.	Histamine (Histamine Dihydrochloride)
10.	Chlorpromazine (Thorazine)