mepenzolic acid (Cantil)

anticholinergic, antispasmodic agent; RN given refers to parent cpd; structure

Also Known As:

Cantil; mepenzolate bromide; mepenzolate; N-methyl-3-piperidylbenzilate methyl bromide; mepenzolate bromide, (+-)-isomer; mepenzolate iodide; mepenzolic acid, bromine salt; mepenzolic acid, bromine salt, 1-(methyl-(14)C)-labeled

Networked: 13 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Mizushima, Tohru: 4 articles (07/2014 - 01/2013)
2.	Asano, Teita: 3 articles (07/2014 - 03/2014)
3.	Ishihara, Tomoaki: 3 articles (07/2014 - 01/2013)
4.	Kobayashi, Daisuke: 3 articles (07/2014 - 01/2013)
5.	Suzuki, Hidekazu: 3 articles (07/2014 - 01/2013)
6.	Tanaka, Ken-Ichiro: 3 articles (07/2014 - 01/2013)
7.	Yamakawa, Naoki: 3 articles (07/2014 - 01/2013)
8.	Yamashita, Yasunobu: 3 articles (07/2014 - 01/2013)
9.	Kurotsu, Shota: 2 articles (07/2014 - 03/2014)
10.	Sugizaki, Toshifumi: 2 articles (07/2014 - 01/2013)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2013 - "Based on these results, we propose that mepenzolate bromide may be an effective therapeutic for the treatment of COPD due to its anti-inflammatory and bronchodilatory activities. " 07/01/2014 - "These results suggest that (R)-mepenzolate may have superior properties to (S)-mepenzolate as a drug to treat COPD patients given that the former has more potent bronchodilatory activity than the latter. " 03/28/2014 - "These results suggest that the pulmonary route of mepenzolate administration may be superior to other routes (oral, intravenous or intrarectal) to treat COPD patients. " 03/28/2014 - "Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease." 01/01/2013 - "Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease."
2.	Pulmonary Emphysema 03/28/2014 - "Oral administration of mepenzolate caused not only bronchodilation but also decreased the severity of elastase-induced pulmonary emphysema; however, compared with the intratracheal route of administration, about 5000 times higher dose was required to achieve this effect. "
3.	Pulmonary Fibrosis (Fibrosing Alveolitis) 07/01/2014 - "Ameliorative effect of mepenzolate bromide against pulmonary fibrosis." 07/01/2014 - "In the present study, we examined the effect of mepenzolate on bleomycin-induced pulmonary fibrosis and lung dysfunction in mice. " 07/01/2014 - "These results show that the intratracheal administration of mepenzolate reduced bleomycin-induced pulmonary fibrosis and lung dysfunction in mice. " 07/01/2014 - "Intratracheal administration of mepenzolate prior to bleomycin treatment reduced the extent of pulmonary fibrosis and changes in lung mechanics and led to a significant recovery of both FVC and SpO2 compared with control. " 01/01/2016 - "Mepenzolate bromide, which was originally used to treat gastrointestinal disorders in clinical settings, has recently been shown to display beneficial effects in chronic obstructive pulmonary disease and pulmonary fibrosis of a mouse model by inhibiting inflammatory responses and reducing oxidative stress. "
4.	Wounds and Injuries (Trauma) 01/01/2016 - "In this study, full-thickness excisional skin wounds were created on the backs of db/db mice, and mepenzolate bromide was topically applied to the wound bed. " 01/01/2016 - "We found that mepenzolate bromide significantly promoted diabetic wound healing by measuring wound closure rate and histomorphometric analyses. " 01/01/2016 - "These results demonstrated the potential application of mepenzolate bromide for treating diabetic ulcers and other chronic wounds in clinics. "
5.	Diarrhea 06/01/1983 - "Seventy adults in the United States with acute diarrhea who were attending classes in Guadalajara, Mexico, enrolled in a double-blind placebo-controlled treatment study of an anticholinergic drug, mepenzolate bromide (MZB). "

Related Drugs and Biologics

1.	mepenzolic acid (Cantil)
2.	Muscarinic Antagonists
3.	Pancreatic Elastase (Elastase)
4.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
5.	Cholinergic Antagonists (Anticholinergics)
6.	Bleomycin (Blenoxane)
7.	Therapeutic Uses
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	Venoms
10.	Niacin (Nicotinic Acid)

Related Therapies and Procedures

1.	Oral Administration