1,N(6)-ethenoadenine

biologically active fluorescent derivatives of this cpd potentially valuable in studies concerning interactions between adenine cpds & various enzymes for which they serve as substrates or co-factors; structure

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tudek, Barbara: 2 articles (06/2007 - 08/2003)
2.	Barbin, Alain: 2 articles (11/2003 - 08/2003)
3.	Egloff, David: 1 article (02/2015)
4.	Freisinger, Eva: 1 article (02/2015)
5.	Oleinich, Igor A: 1 article (02/2015)
6.	Basu, Ashis K: 1 article (03/2008)
7.	Burke, Tom J: 1 article (03/2008)
8.	McGregor, W Glenn: 1 article (03/2008)
9.	Mukhopadhyay, Suparna: 1 article (03/2008)
10.	Tolentino, Joel H: 1 article (03/2008)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 06/01/2007 - "These include 8-oxoguanine (8-oxoG) repair in lung and head and neck cancer patients and repair of lipid peroxidation (LPO) induced 1,N(6)-ethenoadenine (epsilonA) in lung cancer patients. " 08/01/2003 - "To assess the role of oxidative stress and lipid peroxidation (LPO) in the pathogenesis of lung cancer, we measured the levels of 1,N(6)-ethenoadenine (epsilonA) and 3,N(4)-ethenocytosine (epsilonC) in the DNA by immunoaffinity/(32)P postlabeling (33 cases). "
2.	Carcinogenesis 11/15/2003 - "Increased formation and persistence of 1,N(6)-ethenoadenine in DNA is not associated with higher susceptibility to carcinogenesis in alkylpurine-DNA-N-glycosylase knockout mice treated with vinyl carbamate."
3.	Xeroderma Pigmentosum (Kaposi's Disease) 03/01/2008 - "Comparative mutagenesis of 1,N(6)-ethenoadenine (epsilonA) and 8-oxoguanine (8-oxoG), two endogenous DNA lesions that are also formed by exogenous DNA damaging agents, have been evaluated in HeLa and xeroderma pigmentosum variant (XPV) cell extracts. "
4.	Neoplasms (Cancer) 11/15/2003 - "Mutation spectra in tumors induced in mice by urethane or its metabolite vinyl carbamate (Vcar) are compatible with 1,N(6)-ethenoadenine (epsilonA) being an initiating lesion in the development of these tumors. "
5.	Inflammation (Inflammations) 02/20/2015 - "DNA lesions such as 1,N(6)-ethenoadenine (εA) and 3,N(4)-ethenocytosine (εC) are ubiquitously present in genomes of different organisms and show increasing levels upon exposure to mutagenic substances or under conditions of chronic inflammations and infections. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	8-hydroxyguanine
3.	3,N(4)-ethenocytosine
4.	Urethane (Ethyl Carbamate)
5.	Cell Extracts
6.	vinyl carbamate