guanadrel (Hylorel)

07/01/1988 - "Our conclusion is that guanadrel is an effective, well-tolerated medication for treatment of hypertension in the elderly."
07/01/1983 - "Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension."
04/24/1981 - "Guanadrel should be an effective step II or step III drug for treatment of hypertension."
01/01/1983 - "In light of the efficacy without severe side effects, guanadrel may be an agent for step II therapy of hypertension."
11/01/1982 - "Guanadrel sulfate compared with methyldopa for mild and moderate hypertension."

07/01/1985 - "In comparative studies, guanadrel was comparable in efficacy with guanethidine or methyldopa in mild to moderately severe hypertension, although generally it caused fewer central nervous system side effects than methyldopa and less orthostatic dizziness and diarrhoea than guanethidine. "

07/01/1985 - "A dose-titration trial of guanadrel as step-two therapy in essential hypertension."
11/01/1985 - "Addition of guanadrel to diuretic therapy in 11 patients with essential hypertension reduced supine intra-arterial blood pressure from 135 +/- 14/76 +/- 9 to 127 +/- 13/67 +/- 5 mm Hg (P less than 0.02). "
07/01/1985 - "The efficacy and safety of low-dose guanadrel sulfate were evaluated in 20 patients with essential hypertension based on seated diastolic blood pressures (SDBP) ranging from 95 to 115 mm Hg despite a trial dosage of hydrochlorothiazide 50 mg/d for up to five weeks. "
01/01/1983 - "Eighteen patients with essential hypertension uncontrolled by hydrochlorothiazide alone were randomly assigned to receive additional therapy with either guanadrel sulfate or guanethidine sulfate. "

02/01/1989 - "Thus, the disposition of guanadrel is significantly altered in the presence of renal insufficiency and dosage adjustments may be necessary, especially in patients with ClCr less than 50 ml/min."

07/01/1978 - "We conclude that guanadrel sulfate may be useful in the symptomatic management of patients with thyrotoxicosis."
07/01/1978 - "Effects of guanadrel on patients with thyrotoxicosis."