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eleostearic acid

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RN given refers to cpd with unspecified isomeric designation

Also Known As:

9,11,13-CLN; 9,11,13-conjugated linolenic acid; 9,11,13-octadecatrienoic acid; 9c,11t,13t-CLN; 9cis,11trans,13trans-conjugated linolenic acid; eleostearic acid, (E,E,E)-isomer; eleostearic acid, (E,Z,E)-isomer; eleostearic acid, (Z,E,E)-isomer; eleostearic acid, (Z,Z,E)-isomer; trichosanic acid

Networked: 15 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 18571
- Fatty Acids: 6864
  - Unsaturated Fatty Acids: 3881
    - Essential Fatty Acids: 522
      - Linolenic Acids: 69
        eleostearic acid: 15
    - Linolenic Acids: 69
      - eleostearic acid: 15

Experts

1.	Hontecillas, Raquel: 2 articles (06/2013 - 01/2011)
2.	Lu, Pinyi: 2 articles (06/2013 - 01/2011)
3.	Bassaganya-Riera, Josep: 2 articles (06/2013 - 01/2011)
4.	Yun, Cheol-Heui: 2 articles (02/2010 - 01/2010)
5.	Eom, Jung-Min: 2 articles (02/2010 - 01/2010)
6.	Tsuzuki, Tsuyoshi: 2 articles (04/2008 - 08/2004)
7.	Yuan, Gaofeng: 1 article (02/2015)
8.	Chen, Xiaoe: 1 article (02/2015)
9.	Li, Duo: 1 article (02/2015)
10.	Zou, Zu-Quan: 1 article (03/2014)

Related Diseases

1.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/01/2011 - "Dietary α-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-γ." 02/25/2015 - "This review summarizes the current understanding of evidence of the role of CLA (cis-9,trans-11 CLA and trans-10,cis-12 CLA) and CLNA (punicic acid and α-eleostearic acid) in modulating the expression or activity of PPAR γ that could in turn be employed as complementary treatment for obesity and inflammatory bowel disease. "
2.	Neoplasms (Cancer) 03/01/2014 - "α-eleostearic acid (α-ESA) has been shown to possess antitumor activity in cancer cells. " 01/01/2012 - "Alpha-eleostearic acid (α-ESA) is a natural and biologically active compound which possesses potent antioxidant and anti-tumor activity. " 02/01/2010 - "Alpha-eleostearic acid (alpha-ESA) is known to suppress the growth in cancer cells although its underlying molecular mechanisms have not been fully elucidated. " 11/26/2008 - "Therefore, the effect of alpha-eleostearic acid on the growth of some cancer and normal cell lines was examined. " 08/01/2004 - "In this study we have compared the suppressive effect on tumor growth of alpha-eleostearic acid (alpha-ESA, 9Z11E13E-18:3) with those of the CLA isomers 9Z11E-CLA and 10E12Z-CLA, using nude mice into which DLD-1 human colon cancer cells were transplanted. "
3.	Colonic Neoplasms (Colon Cancer) 08/01/2004 - "In this study we have compared the suppressive effect on tumor growth of alpha-eleostearic acid (alpha-ESA, 9Z11E13E-18:3) with those of the CLA isomers 9Z11E-CLA and 10E12Z-CLA, using nude mice into which DLD-1 human colon cancer cells were transplanted. " 05/01/2006 - "beta-Eleostearic acid and beta-calendic acid, which have all-trans-conjugated double bonds, exerted stronger growth inhibition and more DNA fragmentation, an indicator of apoptosis induction, in the human colon cancer cells Caco-2 than alpha-eleostearic acid and alpha-calendic acid with the cis configuration. " 01/01/2006 - "Troglitazone and 9c,11t,13t-CLN decreased cell viability and induced apoptosis in three colon cancer cell lines. " 01/01/2006 - "Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines."
4.	Breast Neoplasms (Breast Cancer) 03/01/2014 - "Α-eleostearic acid inhibits growth and induces apoptosis in breast cancer cells via HER2/HER3 signaling." 01/01/2012 - "Growth inhibition and apoptotic effect of alpha-eleostearic acid on human breast cancer cells." 10/01/2009 - "Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism." 02/01/2010 - "Alpha-eleostearic acid suppresses proliferation of MCF-7 breast cancer cells via activation of PPARgamma and inhibition of ERK 1 / 2."
5.	Obesity 02/25/2015 - "This review summarizes the current understanding of evidence of the role of CLA (cis-9,trans-11 CLA and trans-10,cis-12 CLA) and CLNA (punicic acid and α-eleostearic acid) in modulating the expression or activity of PPAR γ that could in turn be employed as complementary treatment for obesity and inflammatory bowel disease. "

Related Drugs and Biologics

1.	alpha-Linolenic Acid (Linolenic Acid)
2.	PPAR gamma
3.	punicic acid
4.	Peroxisome Proliferator-Activated Receptors (PPAR)
5.	Linoleic Acid (Linoleate)
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Abscisic Acid
8.	calendic acid
9.	troglitazone (Rezulin)