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3-cyanoalanine

RN given refers to cpd without isomeric designation

Also Known As:

3-cyanoalanine, (D)-isomer; 3-cyanoalanine, (L)-isomer; beta-cyano-D-alanine; beta-cyano-L-alanine; beta-cyanoalanine

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Alanine: 4133
    - 3-cyanoalanine: 7

Experts

1.	Kawabata, Atsufumi: 2 articles (07/2010 - 11/2007)
2.	Maeda, Yumi: 2 articles (07/2010 - 11/2007)
3.	Nishikawa, Hiroyuki: 2 articles (07/2010 - 11/2007)
4.	Sekiguchi, Fumiko: 2 articles (07/2010 - 11/2007)
5.	Takahashi, Tomoko: 2 articles (07/2010 - 11/2007)
6.	Aoki, Yuka: 1 article (07/2010)
7.	Mitani, Kenji: 1 article (07/2010)
8.	Okubo, Kazumasa: 1 article (07/2010)
9.	Dong, Li: 1 article (05/2010)
10.	Jiang, Lin-Hua: 1 article (05/2010)

Related Diseases

1.	Hyperalgesia 07/01/2010 - "administration of dl-propargylglycine (PPG) and beta-cyanoalanine, irreversible and reversible CSE inhibitors, respectively, strongly suppressed the neuropathic hyperalgesia/allodynia. " 11/01/2007 - "L-Cysteine, an endogenous source for H(2)S, given i.pl., also elicited hyperalgesia, an effect being abolished by DL-propargylglycine (PPG) and beta-cyanoalanine (BCA), inhibitors of cystathionine-gamma-lyase, a H(2)S synthesizing enzyme. "
2.	Dehydration (Water Stress) 12/01/1990 - "Synthesis and crystal structures of Boc-L-Asn-L-Pro-OBzl.CH3OH and dehydration side product, Boc-beta-cyano-L-alanine-L-Pro-OBzl." 04/01/1996 - "Coupling of Fmoc-Asn-OH by DCC-HOBt method was shown to be accompanied by a side reaction of dehydration of asparagine amide function with the formation of side product (22%) containing 3-cyanoalanine residue. "
3.	Shock 12/01/2004 - "Pre-treatment (30 min before shock) or post-treatment (60 min after shock) with inhibitors of cystathionine gamma lyase (CSE; converts cysteine into hydrogen sulphide (H(2)S)), dl-propargylglycine or beta-cyanoalanine (50 mg kg(-1), i.v.), or glibenclamide (40 mg kg(-1), i.p.), produced a rapid, partial restoration in MAP and HR. Neither saline nor DMSO affected MAP or HR. Plasma H(2)S concentration was elevated 60 min after blood withdrawal (37.5+/-1.3 microM, n=18 c.f. "
4.	Lathyrism 03/01/1962 - "Isolation and identification from common vetch of the neurotoxin beta-cyano-L-alanine, a possible factor in neurolathyrism."
5.	Hypoxia (Hypoxemia) 05/15/2010 - "The chemoreceptor afferent activation by hypoxia was decreased remarkably using CBS inhibitors, amino oxyacetic acid (AOAA) and hydroxylamine, but not CSE inhibitors, propargylglycine and beta-cyano-L-alanine, despite expression of both enzymes in type I glomus cells. "

Related Drugs and Biologics

1.	propargylglycine
2.	Enzymes
3.	Cysteine (L-Cysteine)
4.	Cystathionine gamma-Lyase (Cysteine Desulfhydrase)
5.	Hydroxylamine (Hydroxylamine Hydrochloride)
6.	Neurotoxins
7.	Hydrogen
8.	Glyburide (Glibenclamide)
9.	Dimethyl Sulfoxide (DMSO)
10.	Asparagine