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bietaserpine
hypotensive agent; structure
Also Known As:
1-diethylaminoethylreserpine; DL-152; diethylaminoreserpine; methyl 13-(2-diethylaminoethyl)-2,11-dimethoxy-3-(3,4,5-trimethoxybenzoyloxy)yohimban-1-carboxylic acid
Networked:
5
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Yohimbine: 901
Reserpine: 2387
bietaserpine: 5
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Yohimbine: 901
Reserpine: 2387
bietaserpine: 5
Indolizines: 3
Indolizidines: 2
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Yohimbine: 901
Reserpine: 2387
bietaserpine: 5
Related Diseases
1.
Neoplasms (Cancer)
08/01/1982 - "
Significant reduction in surviving fraction was seen for doses of DL-152 as low as 5 mg/kg. Using KHT tumors growing as lung nodules, it was shown that toxicity of DL-152 was not apparent until 11 to 14 days after initiation of the tumor and that subsequent sensitivity of cells to DL-152 increased with increasing age of the lung tumor.
"
08/01/1982 - "
Hypoxic cells were detectable in 10-day-old lung tumors, a time at which the tumors were still resistant to the toxic effects of DL-152.
"
08/01/1982 - "
injection of diethylaminoreserpine (DL-152) to the tumor-bearing mouse.
"
08/01/1982 - "
Toxicity of diethylaminoreserpine to a transplantable tumor: the significance of the presence of hypoxic cells.
"
03/01/1982 - "
Toxicity of diethylaminoreserpine to tumor cells: effects of drug alone and in combination with radiation.
"
2.
Fibrosarcoma
04/01/1980 - "
Diethylaminoreserpine (DL-152), an inhibitor of cyclic AMP phosphodiesterase, has been shown to kill clonogenic cells of the KHT fibrosarcoma when the drug is given intraperitoneally to the tumour-bearing mouse.
"
01/01/1987 - "
DL-152 was found to be toxic to cells of all the tumor models tested (KHT fibrosarcoma, RIF-1 fibrosarcoma, EMT-6 adenocarcinoma and Lewis lung carcinoma) when the drug was given by intraperitoneal injection to the tumor-bearing mouse and cell survival was measured by excision assay.
"
3.
Lewis Lung Carcinoma
01/01/1987 - "
DL-152 was found to be toxic to cells of all the tumor models tested (KHT fibrosarcoma, RIF-1 fibrosarcoma, EMT-6 adenocarcinoma and Lewis lung carcinoma) when the drug was given by intraperitoneal injection to the tumor-bearing mouse and cell survival was measured by excision assay.
"
4.
Hypertension (High Blood Pressure)
05/20/1967 - "
[Treatment of arterial hypertension with a new reserpine derivative: bietaserpine].
"
5.
Adenocarcinoma
01/01/1987 - "
DL-152 was found to be toxic to cells of all the tumor models tested (KHT fibrosarcoma, RIF-1 fibrosarcoma, EMT-6 adenocarcinoma and Lewis lung carcinoma) when the drug was given by intraperitoneal injection to the tumor-bearing mouse and cell survival was measured by excision assay.
"
Related Drugs and Biologics
1.
Reserpine (Serpasil)
2.
Phosphoric Diester Hydrolases (Phosphodiesterases)
3.
Cyclic AMP (AMP, Cyclic)
Related Therapies and Procedures
1.
Intraperitoneal Injections