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benzarone

antihemorrhagic agent; structure

Also Known As:

EHBB; benzaron; 2-ethyl-3-(4'-hydroxybenzoyl)benzofuran

Networked: 18 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - Benzbromarone: 213
        benzarone: 18

Experts

1.	Hegde, Rashmi S: 2 articles (01/2021 - 01/2012)
2.	Pandey, Ram Naresh: 2 articles (01/2021 - 01/2012)
3.	Kalin, Tanya V: 1 article (01/2021)
4.	Milewski, David: 1 article (01/2021)
5.	Pressey, Joseph G: 1 article (01/2021)
6.	Roychoudhury, Kaushik: 1 article (01/2021)
7.	Szabo, Sara: 1 article (01/2021)
8.	Wang, Yuhua: 1 article (01/2021)
9.	Lang, Richard A: 1 article (01/2012)
10.	Sumanas, Saulius: 1 article (01/2012)

Related Diseases

1.	Intermittent Claudication 02/22/1980 - "For the first time, positive results were shown with Benzarone in patients with intermittent claudication." 02/22/1980 - "We report the results of a pilot study to evaluate the therapeutical efficiency of Benzarone in a time span of four weeks in 11 male patients with intermittent claudication. " 03/04/1983 - "[Behavior of muscle tissue oxygen pressure in patients with severe intermittent claudication after oral administration of benzarone]."
2.	Neoplasms (Cancer) 07/01/2022 - "Administration of EYA3 inhibitor (benzarone) in mice harboring tumor xenografts significantly inhibited tumor growth. " 01/01/2021 - "Target engagement is demonstrated in tumor tissue through elevated levels of the EYA3 substrate H2AX-pY142 upon loss of EYA3 or with Benzarone treatment. " 07/15/1970 - "[Effect of benzarone on local reactive processes in patients undergoing radiotherapy for malignant neoplasms]." 01/01/2012 - "Taken together our results demonstrate that the EYA tyrosine phosphatase activity is pro-angiogenic and that Benzbromarone and Benzarone are attractive candidates for repurposing as drugs for the treatment of cancer metastasis, tumor angiogenesis, and vasculopathies."
3.	Hepatitis 09/01/1990 - "This case represents the third reported case of severe hepatitis related to benzarone. " 01/01/1990 - "[Hepatitis caused by benzarone: a second case]." 06/01/1994 - "Subfulminant hepatitis requiring liver transplantation after benzarone administration." 09/01/1990 - "A 46-year-old woman with a previous history of thyroiditis but without clinical evidence of preexisting liver disease presented with severe acute hepatitis while under benzarone therapy (Fragivix, 400 mg per day, p.o.). "
4.	Edema (Dropsy) 04/22/1983 - "[Benzarone for leg edema caused by chronic venous insufficiency]." 01/01/1978 - "Benzarone, 2.5 mg/kg i.v., inhibited the development of the protein edemas when injected before the application of the edema producing substances. " 01/01/1978 - "[Effects of benzarone on the chloroform edema of the mouse and on the petechiae test in the guinea pig (author's transl)]." 01/01/1978 - "In polidocanol and thiopental-induced edemas--except for the thiopental-induced skin edema that was less marked even in the controls--benzarone had a significant effect."
5.	Chronic Hepatitis (Chronic Active Hepatitis) 02/01/1995 - "We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis. " 12/01/1987 - "Chronic active hepatitis caused by benzarone." 12/01/1987 - "We report a case of chronic active hepatitis caused by benzarone, a benzofuran derivative used in Europe for the treatment of peripheral venous disorders. "

Related Drugs and Biologics

1.	Cholesterol
2.	Benzbromarone
3.	Tyrosine (L-Tyrosine)
4.	Thiopental (Pentothal)
5.	Proteins (Proteins, Gene)
6.	Phosphoric Monoester Hydrolases (Phosphatases)
7.	Oxygen (Dioxygen)
8.	Lipids
9.	Chloroform (Trichloromethane)
10.	Ascorbic Acid (Vitamin C)

Related Therapies and Procedures

1.	Liver Transplantation
2.	Therapeutics
3.	Radiotherapy
4.	Oral Administration