2-phenylphenol (orthophenylphenol)

RN given refers to parent cpd; structure

Also Known As:

orthophenylphenol; 2-hydroxybiphenyl; 2-hydroxydiphenyl; 2-phenylphenol sodium; Dowicide; Lyorthol; o-phenylphenate; o-phenylphenol; ortho-phenylphenate; sodium o-phenylphenoate; sodium ortho-phenylphenate; sodium ortho-phenylphenol; (1,1'-biphenyl)-2-ol

Networked: 31 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        2-phenylphenol: 31

Experts

1.	Balakrishnan, S: 2 articles (04/2016 - 08/2006)
2.	Eastmond, D A: 2 articles (04/2016 - 08/2006)
3.	Yamamoto, Ayumi: 2 articles (01/2010 - 11/2008)
4.	Yamamoto, Kazuo: 2 articles (01/2010 - 11/2008)
5.	Hasegawa, L: 1 article (04/2016)
6.	Nakata, Yuichiro: 1 article (01/2013)
7.	Nishi, Kosuke: 1 article (01/2013)
8.	Nishimoto, Sogo: 1 article (01/2013)
9.	Sugahara, Takuya: 1 article (01/2013)
10.	Shiga, Takeki: 1 article (01/2010)

Related Diseases

1.	Neoplasms (Cancer) 03/01/1986 - "There were also no tumor-enhancing (or tumor-inhibiting) effects of o-phenylphenol and DMBA given in combination. " 04/01/1993 - "The total covalent bindings in skin DNA produced by treatment of mice with 10 mg and 20 mg Na-o-phenylphenol (doses shown to be effective for tumor promotion) were 0.31 fmoles/microgram DNA and 0.62 fmoles/microgram DNA, respectively. " 10/01/1991 - "The results of these studies show that both technical penta and Dowicide EC-7 are carcinogenic for mice, causing neoplasms in multiple organs/systems. " 03/01/1989 - "In situ freezing of the urinary bladder: a trigger of rapid development of sodium o-phenylphenate-induced urinary bladder tumors in the rat." 03/01/1986 - "Moreover, a complete histopathologic review revealed no other neoplasms at any other site at significantly increased incidences in the groups receiving o-phenylphenol compared with the acetone vehicle controls. "
2.	Carcinogenesis 03/01/1986 - "o-Phenylphenol is used primarily as a germicide and fungicide for citrus fruits and vegetables and was selected for carcinogenesis studies because of the potential for human exposure. " 09/01/1989 - "Co-carcinogenic effects of NaHCO3 on o-phenylphenol-induced rat bladder carcinogenesis." 03/01/1986 - "Carcinogenesis studies were conducted to determine whether o-phenylphenol was a complete carcinogen for skin or a promoter in a two-stage initiation/promotion skin paint model. " 03/01/1986 - "NTP Toxicology and Carcinogenesis Studies of o-Phenylphenol (CAS No. 90-43-7) Alone and with 7,12-Dimethylbenz(a)anthracene (CAS No. 57-97-6) in Swiss CD-1 Mice (Dermal Studies)." 07/01/1997 - "Effects of pH on nonenzymatic oxidation of phenylhydroquinone: potential role in urinary bladder carcinogenesis induced by o-phenylphenol in Fischer 344 rats."
3.	Papilloma (Papillomatosis) 03/01/1986 - "Similarly, the mean time of appearance of skin papillomas occurred much earlier in the DMBA/TPA groups than in the DMBA/acetone or DMBA/o-phenylphenol groups. " 11/01/1984 - "o-Phenylphenol (OPP), a fungicide approved as a food additive in Japan, was given in pelleted diets at dietary levels of 0.156, 0.313, 0.625, 1.25 or 2.5% to groups of 11 or 12 F344/DuCrj rats of each sex for 13 wk, and 0.625, 1.25 or 2.5% to groups of 20-24 male F344/DuCrj rats for 91 wk. In the 13-wk study, transitional cell papillomas of the urinary bladder occurred in 6/12 (50%) of the male 1.25% group. " 09/01/1985 - "Additions of sodium saccharin (5%), sodium o-phenylphenate (2%), butylated hydroxyanisole (2%), and sodium L-ascorbate (5%) to the diet had significant promoting effects on the incidences and numbers of PN hyperplasias and papillomas per 10 cm of basement membrane of the urinary bladder in this system. " 03/01/1986 - "Skin neoplasms classified as squamous cell papillomas, squamous cell carcinomas, basal cell tumors, basal cell carcinomas, keratoacanthomas, or sebaceous adenomas occurred in mice dosed with DMBA/acetone, DMBA/o-phenylphenol, or DMBA/TPA alone. "
4.	Body Weight (Weight, Body) 03/01/1986 - "In the 2-year studies, mean body weights of the o-phenylphenol, DMBA/o-phenylphenol, and DMBA/TPA groups were not markedly different from those of mice that received DMBA/acetone. " 03/01/1986 - "Reductions in body weights of acetone vehicle control were observed, but no compound-related changes in weight or survival occurred in male or female mice administered o-phenylphenol. "
5.	Chromosome Aberrations (Chromosome Abnormalities) 10/01/1984 - "Induction of chromosome aberrations and sister-chromatid exchanges in CHO-K1 cells by o-phenylphenol." 05/01/1989 - "The effects of microsomal activation and/or deactivation on the induction of chromosomal aberrations and sister-chromatid exchanges (SCEs) in cultured Chinese hamster ovary cells (CHO-K1 cells) by o-phenylphenol (OPP) were studied, and concurrently the metabolites were determined. " 04/01/1993 - "These results indicate that both numerical and structural chromosomal aberrations induced by the quinone metabolites of benzene and o-phenylphenol may play a role in the carcinogenic effects of these two agents." 01/01/1991 - "The effects of cysteine and reduced glutathione (GSH) on the genotoxicity of o-phenylphenol (OPP) and its metabolites, phenylhydroquinone (PHQ) and phenylbenzoquinone (PBQ), were examined using the frequency of sister-chromatid exchanges (SCEs) and chromosome aberrations in CHO-K1 cells as parameters. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	4-(2-oxapentadeca-4-yne)phenylpropanoic acid
3.	Sodium
4.	Carcinogens
5.	Disinfectants (Biocides)
6.	9,10-Dimethyl-1,2-benzanthracene
7.	Pentachlorophenol (Sodium Pentachlorophenate)
8.	Food Additives (Food Additive)
9.	Acetone
10.	PENTA