thiobutabarbital (Inactin)

02/01/1991 - "1. In order to document the characteristics of the renal vascular response to blood losses of varying severity, Inactin-anaesthetized rats were subjected to a haemorrhage of 5, 10, 15 or 20 ml (kg body weight)-1, while a fifth group (control rats) remained unbled. "
09/03/1976 - "Inactin, given to rats for anaesthesia at a dose of 100 mg per kg body weight results in an arterial plasma concentration of 10.6 +/- 1.14 mg%, measured 40 min after the onset of anaesthesia. "
02/22/1978 - "The ability to excrete a volume of isotonic saline equal to 10% of body weight infused over 60 min, was examined in awake rats and in rats anesthetized with 1 of the 2 agents most commonly used in renal clearance studies, Inactin or Nembutal. "
01/01/2000 - "Under inactin (120 mg/kg, body weight) anesthesia, rats were instrumented to record blood pressure and dP/dt (Millar catheter) and urine was collected through a suprapubic urinary bladder catheter. "
08/01/1975 - "The renal effects of i.v. saline loading equal to 1% body weight (b.wt.) were studied in 2 groups of rats: group I was anesthetized with Amytal (15 mg/100 g b.wt. plus supplementary doses), group II with Inactin (12.5-15.0 mg/100 g b.wt.). "

01/01/1955 - "[First trial of pre-treatment with pacatal in inactin-ether narcosis in gynecology]."
01/01/1978 - "[Influence of duration and depth of ether of brevinarcon narcosis on the cerebral acetylcholine content of rat]."
11/06/1954 - "[Narcosis with Inactin (thiobutabarbital)]."
01/01/1978 - "For decapitation of rats in order to determine brain acetylcholine (Ach) content the animals may be anaesthesized slightly by ether no longer than for 2 min, since forebrain Ach content increases quickly up to about 170% throughout the following 3 min. The progress of brain Ach content up to its maximum level is decided both by duration and degree of cns depression: In the moment of most distinctly marked Brevinarcon -narcosis -- evident 2,5 min after i. v. injection (40 mg/kg) -- the forebrain Ach content merely is increased by about 15%, but when anaesthesia is reduced considerably again -- 2,5 min later -- the Ach content only reaches its maximum level."

03/01/2008 - "Endotoxemia was induced in thiobutabarbital-anesthetized rats (n = 9 per group) by infusion of LPS (dosage, 1 mg/kg per hour i.v.). "
03/01/2007 - "Endotoxemia was induced in thiobutabarbital-anesthetized rats by an intravenous bolus dose of lipopolysaccharide (LPS; 6 mg/kg). "
04/01/2003 - "This study examined the effects of 1400 W (N-3-aminomethyl-benzyl-acetamidine), a new selective inhibitor of inducible NOS (iNOS), relative to those of N(G)-nitro-L-arginine (L-NNA, non-selective inhibitor of NOS) and the vehicle, on mean arterial pressure (MAP), CO, total peripheral resistance (TPR) and tissue blood flow (BF) in thiobutabarbital-anesthetized rats with lipopolysaccharide (LPS, 10 mg/kg, i.v.) induced endotoxemia. "

07/01/1998 - "In Inactin anaesthetized rats, hypothermia at 28 degrees C decreased GFR by 50% but failed to alter efferent renal sympathetic nerve activity (ERSNA). "
07/01/1983 - "Short-lasting hypothermia during thiobutabarbital general anaesthesia causes no decrease of the absolute ATP level in the blood and liver of rats. "
01/01/1993 - "The study was aimed at establishing whether exogenous insulin administered to rats subjected to brief hypothermia and having the shivering thermogenesis blocked by thiobutabarbital anesthesia can influence rectal temperature, the levels of some hormones and energy metabolism. "
07/01/1998 - "Since hypothermia causes shivering which could have influenced the ERSNA recording, Inactin anaesthetized rats were treated with pethidine or rats were anaesthetized with pentobarbital sodium or Saffan to eliminate cold-induced shivering. "

02/01/1992 - "To investigate intrarenal hemodynamics and effects of alpha 1-adrenergic blockade on glomerular functions in congestive heart failure (CHF), micropuncture studies were performed before and after intravenous injection of terazosin (1 microgram/100 g body wt iv) in eight myocardial infarction (MI) and in nine sham-operated rats after intraperitoneal injection of Inactin (70 mg/kg). "