dexamethasone 21-phosphate

has anti-inflammatory activity

Also Known As:

Decadron phosphate; Solu- Decadron; Spersadex; Spersadox; dexamethasone 21-phosphate, (6alpha,11beta,16alpha)-isomer; dexamethasone 21-phosphate, copper (+2) salt (2:3), (11beta,16alpha)-isomer; dexamethasone 21-phosphate, disodium salt, (11beta,16alpha)-isomer; dexamethasone 21-phosphate, disodium salt, (6alpha,11beta,16alpha)-isomer; dexamethasone 21-phosphate, monosodium salt, (11beta,16alpha)-isomer; dexamethasone 21-phosphate, sodium salt, (11beta,16alpha)-isomer; dexamethasone phosphate; dexamethasone phosphate disodium salt; dexamethasone sodium phosphate; dexamethasonedisodium phosphate

Networked: 220 relevant articles (39 outcomes, 37 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Fluorinated Steroids: 32
      - Dexamethasone: 23151
        dexamethasone 21-phosphate: 220
    - Pregnanes: 9
      - Pregnadienes
        Pregnadienetriols
        Dexamethasone: 23151
        dexamethasone 21-phosphate: 220

Experts

1.	Higuchi, John W: 4 articles (01/2019 - 08/2008)
2.	Higuchi, William I: 4 articles (01/2019 - 08/2008)
3.	Papangkorn, Kongnara: 4 articles (01/2019 - 08/2008)
4.	Wang, Dong: 3 articles (01/2022 - 10/2010)
5.	Brar, Balbir: 3 articles (01/2019 - 12/2017)
6.	Li, Xingyi: 3 articles (01/2019 - 10/2017)
7.	Storm, Gert: 3 articles (01/2019 - 04/2006)
8.	Magnani, Mauro: 3 articles (08/2013 - 07/2004)
9.	Rossi, Luigia: 3 articles (08/2013 - 07/2004)
10.	Lissin, Dmitri: 2 articles (09/2022 - 01/2021)

Related Diseases

1.	Experimental Arthritis 01/01/2020 - "In a collagen-induced arthritis rat model, these AKP-dex-loaded nanoparticles showed higher accumulation in inflamed joints and better therapeutic efficacy than free dexamethasone phosphate with less-severe side effects. " 01/01/2009 - "Therapeutic efficacy and persistence of free and liposomal dexamethasone phosphate (DXM-P) were determined in mouse collagen-induced arthritis. " 01/01/2010 - "The objective of this study was to evaluate the efficacy of intravenous (i.v.) injection of liposomally encapsulated dexamethasone phosphate (DxM-P) in comparison to free DxM-P in rats with established adjuvant arthritis (AA). " 01/01/2010 - "Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis." 01/01/1985 - "Distribution of dexamethasone to the inflammatory lesion in rats with adjuvant arthritis was markedly higher in the liposteroid group than in the dexamethasone phosphate group: 1.5 times higher in 2-6 hours and approximately twice in 24 h. "
2.	Croup 10/01/1983 - "We compared the efficacy of high-dose dexamethasone sodium phosphate (0.6 mg/kg) in laryngotracheitis (LT) v spasmodic croup (SC) in 72 children (age range, 8 months to 8 years) using a double-blind randomized protocol that measured the individual change in respirations as an objective variable to evaluate the outcome. " 04/01/1996 - "To determine if treating children who have acute, moderate croup with nebulized dexamethasone sodium phosphate in the emergency department results in clinical improvement by 4 hours and a decrease in the hospitalization rate. " 12/01/2001 - "To assess the efficacy of oral dexamethasone or nebulized dexamethasone sodium phosphate in children with mild croup. " 09/01/1989 - "Critical assessment of all prospective randomized double-blind placebo-controlled trials reported during the study period shows that there is little information on the use of humidified air or supplemental oxygen, that racemic epinephrine hydrochloride is of well-demonstrated efficacy, and that dexamethasone phosphate at a dose greater than 0.3 mg/kg is effective in decreasing the length and severity of respiratory symptoms associated with viral croup."
3.	Vomiting 06/01/2010 - "The aim of this study was to investigate the cathodal iontophoresis of dexamethasone sodium phosphate (DEX-P) in vitro and in vivo and to determine the feasibility of delivering therapeutic amounts of the drug for the treatment of chemotherapy-induced emesis. " 09/01/2002 - "The aim of the study was to evaluate the efficacy of low-dose dexamethasone sodium phosphate (5 mg) on the prophylaxis of nausea and vomiting after tympanomastoid surgery. " 08/01/2021 - "Physical and Chemical Stability of Dexamethasone Sodium Phosphate in Intravenous Admixtures Used to Prevent Chemotherapy-Induced Nausea and Vomiting." 09/01/2002 - "Dexamethasone sodium phosphate 5 mg was more effective than 2 mg tropisetron hydrochloride and saline in the prevention of nausea and vomiting after tympanomastoid surgery." 01/01/1987 - "The patients received graded doses of dexamethasone phosphate, in the range 40-200 mg, dependent upon nausea and vomiting scores, during up to three consecutive cycles of cancer chemotherapy. "
4.	Uveitis 12/01/2017 - "To investigate the efficacy and safety of dexamethasone sodium phosphate administered through Visulex system (DSP-Visulex) in treating experimental uveitis. " 12/01/2017 - "Noninvasive Ocular Drug Delivery System of Dexamethasone Sodium Phosphate in the Treatment of Experimental Uveitis Rabbit." 01/01/2019 - "Furthermore, topical instillation of Dex-SA-FFFE nanoparticles displayed a comparable in vivo therapeutic efficacy to that of dexamethasone sodium phosphate (Dexp) aqueous solutions in an endotoxin-induced uveitis (EIU) rabbit model. " 08/01/2008 - "The aims of this study were to assess the trans-scleral delivery of dexamethasone phosphate (DexP) with a prototype lens device and a formulation comprising a vasoconstrictor and to determine the efficacy of this delivery system in treating experimentally induced uveitis in a rabbit model. " 12/01/2022 - "We used a rat model of experimental autoimmune uveitis (EAU) to evaluate the effects of SKD MCs in terms of clinical manifestations, molecular biology, pathological histology, and visual electrophysiology compared to dexamethasone sodium phosphate injection or phosphate-buffered saline. "
5.	Pain (Aches) 03/01/2003 - "Dermal iontophoretic administration of dexamethasone sodium phosphate will be significantly more effective in controlling pain than a placebo in patients with medial or lateral elbow epicondylitis. " 01/01/1979 - "We were not able to demonstrate any effect of dexamethasone phosphate on the following parameters pain, paraesthesia, paresismuscular weakness, disturbances of reflexes, and Laseque. " 09/01/2022 - "The pharmacokinetics and pharmacodynamics of dexamethasone following epidural SP-102 or intravenous dexamethasone sodium phosphate injection in subjects with lumbosacral radicular pain." 04/01/2013 - "Phonophoresis of dexamethasone sodium phosphate may manage pain and symptoms of patients with carpal tunnel syndrome." 04/01/2005 - "Iontophoresis with dexamethasone sodium phosphate can relieve pain in acute elbow tendonitis, but there is no support for phonophoresis for any tendonitis. "

Related Drugs and Biologics

1.	Glucocorticoids
2.	Solutions
3.	Steroids
4.	prednisolone acetate
5.	Hydrogels
6.	Dexamethasone (Maxidex)
7.	Endotoxins
8.	Cyclodextrins
9.	Triamcinolone Acetonide (Azmacort)
10.	Ophthalmic Solutions (Eye Drops)

Related Therapies and Procedures

1.	Phonophoresis
2.	Therapeutics
3.	Intravitreal Injections
4.	Intravenous Administration
5.	Injections