anisodamine

alkaloid isolated from Chinese solanacea plant; anticholinergic drug with strong spasmolytic property; activates dopaminergic system; RN refers to (1R-(1alpha,3beta,(S*),5alpha,6alpha)-isomer; structure

Also Known As:

Networked: 122 relevant articles (21 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shen, Hong: 6 articles (03/2015 - 12/2008)
2.	Zhang, Wei: 4 articles (05/2013 - 01/2011)
3.	Xue, Ling: 4 articles (10/2012 - 07/2007)
4.	Liu, Chong: 3 articles (02/2014 - 01/2011)
5.	Dai, Zheng: 3 articles (05/2013 - 02/2013)
6.	Zhang, Jie: 3 articles (05/2013 - 02/2013)
7.	Zhou, Man-hong: 3 articles (05/2013 - 02/2013)
8.	Liu, Ya-hua: 3 articles (05/2013 - 02/2013)
9.	Fu, Xiang-Hua: 3 articles (10/2012 - 07/2007)
10.	Su, Ding-Feng: 2 articles (07/2015 - 01/2011)

Related Diseases

1.	Shock 01/01/2001 - "In this study we aimed to investigate whether the therapeutic efficacy of anisodamine in the treatment of bacteraemic shock could--at least in part--be brought about by its direct interference with the lipopolysaccharide (LPS)-induced activation of endothelial cells. " 12/01/1983 - "[Studies on the anti-shock mechanism of anisodamine. " 01/01/2011 - "The main mechanism of anisodamine for anti-shock proposed in Pharmacology for Chinese medical students is to improve blood flow in the microcirculation. " 01/01/2011 - "Beneficial effects of anisodamine in shock involved cholinergic anti-inflammatory pathway." 01/01/2002 - "The ability of anisodamine to counteract LPS effect on endothelial cells might be one underlying mechanism explaining its antithrombosis and efficacy in the treatment of bacteraemic shock."
2.	Septic Shock (Toxic Shock Syndrome) 03/01/2012 - "Previous studies have proved the renal protective effects of anisodamine in patients with septic shock. " 10/01/2015 - "The present study aimed to investigate the effectiveness of anisodamine in the treatment of septic shock, in the hope that the drug will provide alternatives to the treatment of septic shock. " 08/01/1987 - "[Experimental studies on the effect of anisodamine (654-2) on endotoxic shock]." 01/01/2015 - "[Reunderstanding and prospect of treatment of septic shock with anisodamine]." 03/01/2007 - "The primary therapeutic use of anisodamine has been for the treatment of septic shock. "
3.	Acute Lung Injury 06/01/2013 - "Effects of high dose of anisodamine on the respiratory function of patients with traumatic acute lung injury." 06/01/2013 - "Acute lung injury scores and respiratory parameters were all significantly improved in the two groups of patients after the treatment (P < 0.05); compared with the conventional treatment group, the improvements of respiratory function in the anisodamine treatment group were more obvious (P < 0.05), the mechanical ventilation time was shorter (P < 0.05), and there was no significant adverse reaction. " 06/01/2013 - "The objective of this study is to observe the effects of high dose of anisodamine in the respiratory function of patients with acute lung injury (ALI) induced by trauma. " 02/01/2008 - "[Anisodamine inhalation ameliorates rat acute lung injury caused by oleic acid]." 04/01/1989 - "[Therapeutic effect of anisodamine on acute lung injury induced by oleic acid in dogs]."
4.	Ischemia 06/01/2002 - "To determine if anisodamine is able to augment mucosal perfusion during gut I/R ischemia-reperfusion. " 05/01/2013 - "To investigate the protection of anisodamine on cardiac ischemia/reperfusion (I/R) injury by oxidative stress by observing the changes in oxidation and antioxidant markers in plasma and myocardium, and the damage of cardiac mitochondria structure in pigs with cardiac arrest (CA). " 12/01/1998 - "Our findings indicate that anisodamine protects skeletal muscles with ischemia and reperfusion injury." 12/01/1998 - "We used anisodamine in a rabbit model with ischemia and reperfusion injury of hind limb muscles. " 01/01/2013 - "DADLE after the ischemia showed no benefit, but combined treatment with anisodamine showed a marked postischemic cardioprotection. "
5.	Reperfusion Injury 05/01/2013 - "[Experimental study on the protective effect of anisodamine on flaps with ischemia reperfusion injury]." 05/01/2013 - "So Anisodamine can increase the survival rate of flaps with ischemia reperfusion injury." 05/01/2013 - "To observe the effect of anisodamine (Ani) injection on the survival rate and histologic result of flaps with ischemia-reperfusion injury, so as to demonstrate the protective effect of Ani on the flap survival. " 12/01/1998 - "Protective effect of anisodamine on reperfusion injury of skeletal muscles in rabbit." 08/01/1990 - "It is assumed that anisodamine could protect tissues from reperfusion damage. "

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Related Therapies and Procedures

1.	Ligation
2.	Mastectomy (Mammectomy)
3.	Artificial Respiration (Mechanical Ventilation)
4.	Resuscitation
5.	Intravenous Injections