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IOB 82

RN given refers to parent cpd

Also Known As:

IOB 82, sodium salt; IOB-82; NSC-146171; 3-(bis(2-chloroethyl)amino)-4-methylbenzoic acid

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        IOB 82: 2

Related Diseases

1.	Lymphatic Metastasis 01/01/1970 - "A study of chromosomal behaviour in primary tumour cells and lymphatic metastases under the action of the cytostatic IOB 82."
2.	Polyploidy 07/01/1978 - "IOB-82 treatment produced changes in chromosome numbers and especially the disappearance of polyploid cells and cell populations with 85-86 chromosomes. "
3.	Chromosome Aberrations (Chromosome Abnormalities) 07/01/1978 - "Twenty-four h after IOB-82 treatment (with small or large doses), the chromatid and chromosome aberrations (gaps, breaks, deletions, fragments) were also observed. "
4.	Ascites 07/01/1978 - "Changes produced and their incidence appear to depend on the concentration of IOB-82 employed and the morphological type of ascites cells. " 07/01/1978 - "Morphological and cytogenetical changes in HR-18 rat ascites cells after in vitro 3-[bis(2-chloroethyl)amino]-4-methylbenzoic acid (NSC-146171; IOB-82) administration." 07/01/1978 - "A bifunctional alkylating agent, 3-[Bis(2-chloroethyl) amino]-4-methylbenzoic acid (NSC-146171; IOB-82) was administered in HR-18 rat ascites cell cultures (which presented 2 morphologic cellular types: A and B type cells, genetically, 2 cellular populations having 41-45 and 85-86 chromosomes and cells with high ploidy), and the morphological and cytogenetical effects were related to the compound concentration. "

Related Drugs and Biologics

1.	Cytostatic Agents
2.	Alkylating Agents
3.	Acids