trofosfamide

cyclophosphamide analog; structure

Also Known As:

Genoxal Trofosfamida; Ixoten; N,N,N'-tris(2-chloroethyl)-N'-O-propylene phosphoric acid ester diamide; Z 4828; trophosphamide; N,N-3'-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, 2-oxide

Networked: 72 relevant articles (14 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        Phosphoramide Mustards: 5
        Cyclophosphamide: 25473
        trofosfamide: 72
- Organophosphorus Compounds: 300
  - Phosphoramides: 8
    - Phosphoramide Mustards: 5
      - Cyclophosphamide: 25473
        trofosfamide: 72

Experts

1.	Reichle, Albrecht: 5 articles (10/2018 - 11/2003)
2.	Vogt, Thomas: 3 articles (12/2004 - 11/2003)
3.	Hartmann, Joerg T: 2 articles (01/2020 - 09/2006)
4.	Bechrakis, Nikolaos E: 2 articles (06/2009 - 09/2004)
5.	Fischer, Lars: 2 articles (06/2009 - 09/2004)
6.	Jahnke, Kristoph: 2 articles (06/2009 - 09/2004)
7.	Korfel, Agnieszka: 2 articles (06/2009 - 09/2004)
8.	Thiel, Eckhard: 2 articles (06/2009 - 09/2004)
9.	Wagner, T: 2 articles (10/2006 - 12/2005)
10.	Hafner, Christian: 2 articles (12/2004 - 11/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Maintenance treatment with trofosfamide has been proposed as an effective regimen for some paediatric malignancies. " 10/01/2006 - "In this study, metronomic and conventional trofosfamide were compared on human NSCLC xenograft "LX-1." In vitro cytotoxicity of trofosfamide on tumor and human umbilical cord endothelial cells was determined under normoxic and hypoxic conditions. " 04/01/2007 - "Due to tumor progression after 2 cycles, she was switched to oral trofosfamide (150 mg daily). " 12/01/2004 - "However, the optimal dose of trofosfamide for patients with advanced cancer has not been systematically investigated yet. " 12/01/2004 - "Trofosfamide is increasingly used in the treatment of patients with several types of malignancies. "
2.	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/01/1994 - "Complete remission after repeated trofosfamide treatment in relapsing high-grade malignant non-Hodgkin's lymphoma--a case report." 12/01/1995 - "Trofosfamide is effective in refractory non-Hodgkin's lymphoma." 01/01/1991 - "Twenty-three patients (12 females, 11 males) with malignant non-Hodgkin's lymphoma were treated with oral trofosfamide 50 mg t.i.d. " 01/01/1991 - "Trofosfamide in non-Hodgkin's lymphoma. " 12/01/2002 - "A few studies have shown that trofosfamide, an oral alkylating agent, may be effective as palliative treatment in non-Hodgkin's lymphoma. "
3.	Sarcoma (Soft Tissue Sarcoma) 03/01/2003 - "No objective remission was observed with oral low-dose trofosfamide in heavily pretreated soft tissue sarcoma patients, but almost half of the patients achieved disease stabilisation for half a year. " 03/01/2003 - "Phase II trial of trofosfamide in patients with advanced pretreated soft tissue sarcomas." 01/01/1995 - "Oral trofosfamide: an active drug in the treatment of soft-tissue sarcoma." 03/01/2003 - "The moderate toxicity profile observed in this study allows the consideration of trofosfamide as a reasonable palliative treatment option for patients with soft tissue sarcoma." 06/01/1999 - "This phase II study investigated the activity of continuously administered oral trofosfamide in chemotherapy-pretreated patients with metastatic soft-tissue sarcoma (STS). "
4.	Prostatic Neoplasms (Prostate Cancer) 01/01/2006 - "Palliative chemotherapy with trofosfamide in advanced prostate cancer." 01/01/2010 - "Here, we report a long-term remission over one year in a 68-year-old patient with metastatic docetaxel-refractory prostate cancer employing low-dose trofosfamide. " 01/01/2010 - "Metronomic treatment with low-dose trofosfamide leads to a long-term remission in a patient with docetaxel-refractory advanced metastatic prostate cancer." 01/01/2006 - "A phase II study with trofosfamide in hormone-refractory prostate cancer was conducted to test the palliative efficacy. " 01/01/2006 - "Trofosfamide has some activity in hormone-refractory advanced prostate cancer. "
5.	Intraocular Lymphoma 09/01/2004 - "Treatment of primary intraocular lymphoma with oral trofosfamide: report of two cases and review of the literature." 12/01/2005 - "Pharmacokinetics and efficacy of ifosfamide or trofosfamide in patients with intraocular lymphoma." 06/01/2009 - "We evaluated response, progression-free survival (PFS), overall survival (OS), relapse patterns and long-term toxicity of intraocular lymphoma (IOL) patients treated with ifosfamide (IFO) or trofosfamide (TRO). " 06/01/2009 - "Ifosfamide or trofosfamide in patients with intraocular lymphoma."

Related Drugs and Biologics

1.	Pioglitazone (Actos)
2.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
3.	Etoposide (VP 16)
4.	Alkylating Agents
5.	Ifosfamide
6.	rofecoxib (Vioxx)
7.	Bleomycin (Blenoxane)
8.	Docetaxel (Taxotere)
9.	Rituximab (Mabthera)
10.	PPAR-gamma Agonists

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Palliative Care (Palliative Therapy)
3.	Therapeutics
4.	Induction Chemotherapy
5.	Salvage Therapy