trimethyllysine

stimulates growth of tumor cells; RN given refers to (S)-isomer

Also Known As:

6-N-L-trimethyl-L-lysine; N(6),N(6),N(6)-trimethyl-L-lysine; TRIMETHYLLLYSINE; epsilon-N-trimethyl-L-lysine; epsilon-N-trimethyl-lysine; trimethyllysine chloride, (S)-isomer; trimethyllysine hydroxide, inner salt, (S)-isomer; trimethyllysine hydroxide,inner salt, (+-)-isomer; trimethyllysine, (+-)-isomer; (S)-5-amino-5-carboxy-N,N,N-trimethyl-1- pentanaminium

Networked: 25 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675

Experts

1.	Cheng, Si: 2 articles (01/2022 - 12/2021)
2.	Gao, Jianing: 2 articles (01/2022 - 12/2021)
3.	Zhan, Rui: 2 articles (01/2022 - 12/2021)
4.	Zhao, Mingming: 2 articles (01/2022 - 12/2021)
5.	Zheng, Lemin: 2 articles (01/2022 - 12/2021)
6.	Gu, Xiaodong: 2 articles (01/2019 - 01/2018)
7.	Hazen, Stanley L: 2 articles (01/2019 - 01/2018)
8.	Hurd, Alex G: 2 articles (01/2019 - 01/2018)
9.	Li, Lin: 2 articles (01/2019 - 01/2018)
10.	Li, Xinmin S: 2 articles (01/2019 - 01/2018)

Related Diseases

1.	Hepatitis 01/01/1977 - "In the present paper the effect of the pretreatment with epsilon-amino-trimethyllysine (TML) 10 mg/kg on the DGA-induced hepatitis in mice is described. " 01/01/1977 - "Light and electron microscopic study of hermorrhagic hepatitis induced by trimethyllysine and D-galactosamine."
2.	Carotid Artery Diseases 04/01/2016 - "The aim of this study was to evaluate associations between serum levels of γBB, TMAO and their common precursors Carnitine and trimethyllysine (TML) and carotid atherosclerosis and adverse outcome. "
3.	ST Elevation Myocardial Infarction 01/01/2023 - "Studies about the prognostic role of gut microbiota-derived metabolites including phenylacetyl glutamine (PAGln), indoxyl sulfate (IS), lithocholic acid (LCA), deoxycholic acid (DCA), trimethylamine (TMA), trimethylamine N-oxide (TMAO), and its precursor trimethyllysine (TML) are limited in patients with ST-segment elevation myocardial infarction (STEMI). "
4.	Atherosclerosis 02/02/2023 - "Neither Trimethylamine-N-Oxide nor Trimethyllysine Is Associated with Atherosclerosis: A Cross-Sectional Study in Older Japanese Adults." 10/01/2020 - "The carnitine precursor trimethyllysine (TML) is associated with progression of atherosclerosis, possibly through a relationship with trimethylamine-N-oxide (TMAO). " 01/01/2013 - "The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine."
5.	Heart Failure 11/25/2022 - "Association of Systemic Trimethyllysine With Heart Failure With Preserved Ejection Fraction and Cardiovascular Events." 01/01/2022 - "Trimethyllysine, a trimethylamine N-oxide precursor, predicts the presence, severity, and prognosis of heart failure." 01/01/2022 - "N,N,N-trimethyl-5-aminovaleric acid (TMAVA), derived from trimethyllysine through the gut microbiota, was elevated with gradually increased risk of cardiac mortality and transplantation in a prospective heart failure cohort (n = 1647). " 11/25/2022 - "Carnitine has been associated with cardiac energy metabolism and heart failure, but the association between its precursors-trimethyllysine (TML) and γ-butyrobetaine (GBB)-and heart failure with preserved ejection fraction (HFpEF) remains unclear. "

Related Drugs and Biologics

1.	trimethyloxamine (trimethylamine N-oxide)
2.	Carnitine (L-Carnitine)
3.	Lithocholic Acid
4.	Indican
5.	Glutamine (L-Glutamine)
6.	Galactosamine
7.	Deoxycholic Acid (Sodium Deoxycholate)
8.	trimethylamine
9.	Peptides (Polypeptides)
10.	Lysine (L-Lysine)

Related Therapies and Procedures

1.	Transplantation