tricaprylin

13C-labeled trioctanoin used in breath tests to detect fat malabsorption

Also Known As:

2-ethylhexanoic acid, 1,2,3-propanetriyl ester; Panasate 800; glycerol tricaprylate; glycerol trioctanoate; glyceryl tricaprylate; glyceryl trioctanoate; octanoic acid, 1,2,3- propanetriyl ester; triethylhexanoin; trioctanoin; trioctanoylglyceride

Networked: 47 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Adunyah, Samuel E: 1 article (02/2016)
2.	Amoah, Priscilla: 1 article (02/2016)
3.	Banks, Leah D: 1 article (02/2016)
4.	Niaz, Mohammad S: 1 article (02/2016)
5.	Ramesh, Aramandla: 1 article (02/2016)
6.	Washington, Mary K: 1 article (02/2016)
7.	Hirasawa, Akira: 1 article (01/2015)
8.	Liu, Ning: 1 article (01/2015)
9.	Sanefuji, Hayato: 1 article (01/2015)
10.	Shi, Junfeng: 1 article (01/2015)

Related Diseases

1.	Nephritis 01/01/2015 - "We believe that tricaprylin is the key active antinephritic component of the emulsion and might be a promising drug for the effective treatment of nephritis. "
2.	Neoplasms (Cancer) 01/01/2001 - "Trioctanoin injected intraperitoneally in pregnant rats was associated with an increase in mammary tumors in the offspring compared to that seen in offspring of untreated animals, but similar studies in pregnant hamsters and rabbits showed no tumors in the offspring. " 01/01/2001 - "Trioctanoin injected subcutaneously in hamsters produced no tumors. " 06/01/1990 - "No tumors were found in the control hamsters treated with the vehicle (trioctanoin) alone. " 11/01/1986 - "Tricaprylin-vehicle controls had a mean number of 0.46 +/- 0.15 lung tumors per mouse. " 10/01/1983 - "These tumors were not observed in hamsters injected with trioctanoin. "
3.	Body Weight (Weight, Body) 10/01/1994 - "During the first 20 weeks of the study, these rats were subcutaneously injected with 0, 0.1, or 1.0 mg NNK per kg body weight in trioctanoin three times weekly. " 10/02/2023 - "Supplementation of 2% tricaprylin in HFD significantly increased the body weight, fat mass, liver weight, adipocyte size in adipose tissue and liver, and upregulated genes related to fat deposition. " 06/01/2004 - "After PH they were administered either trioctanoin alone (groups A', B', C' and D') or a single injection of DEN in trioctanoin at a dose of 10 mg/kg of body weight (groups A, B, C and D). " 02/01/2016 - "Mice were assigned to a control (n=8) or treatment group (n=8) consisting of 25, 50 and 100-μg B(a)P/kg body weight (bw) dissolved in tricaprylin [B(a)P-only group] or olive oil daily via oral gavage for 60 days. " 07/01/1998 - "injection of benzo[a]pyrene (B[a]P) (200 mg/kg body weight dissolved in tricaprylin). "
4.	Adenoma (Adenomas) 10/01/1997 - "In tricaprylin-treated control animals, there were 0.67 adenomas/mouse. " 08/01/1996 - "In mice given tricaprylin, the vehicle control, there were 0.60 adenomas/mouse, with 55% of the mice exhibiting an adenoma. " 04/01/1994 - "In the tricaprylin study, there were significant dose-related increased incidences of pancreatic exocrine hyperplasia and adenoma (hyperplasia: 8/49, 9/49, 18/49, 28/50; adenoma: 2/49, 6/49,13/49,18/50 in the untreated control, 2.5, 5, and 10 mL/kg groups, respectively). " 04/01/1994 - "The incidences of mammary gland adenoma and fibroadenoma (combined) were 7/50 for the untreated safflower oil controls and 6/50 for the untreated tricaprylin controls. " 04/01/1994 - "The observed tumor multiplicities (lung adenomas/mouse) were: 97.7 +/- 28.7 at 200 mg/kg, 32.8 +/- 15.4 at 100 mg/kg, 4.63 +/- 2.11 at 50 mg/kg and 0.58 +/- 0.82 at 10 mg/kg. Tricaprylin-treated controls produced 0.60 +/- 0.58 lung adenomas/mouse. "
5.	Carcinogenesis 10/01/1995 - "A single ip dose of B[alpha]P (1.79 mg in 0.25 mL of tricaprylin) resulted in 100% lung tumorigenesis with a multiplicity of 15.79 tumors/mouse. " 01/01/1976 - "Evaluation of beeswax-tricaprylin vehicle for pulmonary carcinogenesis studies." 04/01/1946 - "Factors affecting carcinogenesis; the effect of tricaprylin solutions of cholesterol and phospholipins."

Related Drugs and Biologics

1.	Emulsions
2.	Fatty Acids (Saturated Fatty Acids)
3.	beeswax
4.	Safflower Oil
5.	Fats
6.	Corn Oil (Oil, Corn)
7.	Triolein
8.	Benzo(a)pyrene
9.	octanoic acid (caprylic acid)
10.	Solvents

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Subcutaneous Injections
3.	Catheters
4.	Injections