4-toluenesulfonyl fluoride (TSF)

inhibitor of peptide hydrolases; structure in second source

Also Known As:

TSF; 4-PMSF; alpha-tolylsulfonyl fluoride; p-toluenesulfonyl fluoride; para-toluenesulfonyl fluoride; phenylmethane sulfonyl fluoride; tosyl fluoride; 4-methylbenzenesulfonyl fluoride

Networked: 498 relevant articles (26 outcomes, 82 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Toluene: 931
        Tosyl Compounds
        4-toluenesulfonyl fluoride: 498
- Sulfur Compounds: 278
  - Sulfones: 534
    - Tosyl Compounds
      - 4-toluenesulfonyl fluoride: 498

Experts

1.	Li, Ping: 17 articles (04/2022 - 04/2011)
2.	Zhao, Tingting: 9 articles (10/2021 - 07/2016)
3.	Yan, Meihua: 7 articles (01/2020 - 01/2015)
4.	Coelho, Jennifer S: 7 articles (03/2018 - 02/2008)
5.	Zhang, Haojun: 6 articles (10/2021 - 12/2016)
6.	Brown, Sandra A: 6 articles (01/2013 - 12/2006)
7.	Tate, Susan R: 6 articles (01/2013 - 12/2006)
8.	Wang, Qian: 5 articles (10/2021 - 01/2019)
9.	Kelly, John F: 5 articles (11/2020 - 01/2008)
10.	Dong, Xi: 5 articles (09/2020 - 01/2016)

Related Diseases

1.	Congenital Abnormalities (Deformity) 05/01/2020 - "Intraoperative use of the wake-up test with subsequent TSF fixation is effective and safe for acute correction of limb deformities." 09/01/2023 - "The purpose of this study is to report factors associated with half-pin breakage and compare various deformity correction characteristics between 2 hexapod frames - Taylor Spatial Frame (TSF) and Orthex. " 12/18/2021 - "This study indicates that IMN is a more valuable method of treatment for femoral length discrepancy without axial deformity than MRS and TSF in complication rate and indexes of lengthening and consolidation." 02/14/2020 - "The purpose of this study was to compare the clinical outcomes and radiographic fusions of TSF to TLIF in patients with adult spinal deformity undergoing long fusions across the lumbosacral junction. " 06/01/2017 - "However, there have only been a few studies comparing the use of TSF with various etiologies of the deformity. "
2.	Alcoholism (Alcohol Abuse) 01/01/2008 - "The current study re-examined the Project MATCH (Matching Alcoholism Treatments to Client Heterogeneity) hypothesis that individuals with high network support for drinking would have the best treatment outcomes if they were assigned to twelve-step facilitation (TSF). " 11/01/2020 - "For alcohol addiction severity, one study found evidence of a difference in favor of AA/TSF at 12 months (P < 0.05; low-certainty evidence). " 07/19/2006 - "No experimental studies unequivocally demonstrated the effectiveness of AA or TSF approaches for reducing alcohol dependence or problems. " 07/19/2006 - "Studies involving adults (<18) of both genders with alcohol dependence attending on a voluntary or coerced basis AA or TSF programmes comparing no treatment, other psychological interventions, 12-step variants. " 12/01/2021 - "Many individuals seeking treatment for SUDs also join twelve-step facilitation (TSF) programs like Alcoholics Anonymous (AA), which are among the most widely available and accessed treatments for alcohol use disorder worldwide. "
3.	Wounds and Injuries (Trauma) 01/01/2022 - "The study was a randomized, controlled, open-label (dose-blinded), dose-finding study of 200 subjects who had an open TSF secondary to trauma. " 01/01/2021 - "Our study showed that patient-specific 3D-printed plates for HTO with the use of TSF have the advantages of small trauma, few complications, simple operation, and fast recovery in treating knee OA and varus alignment." 01/01/2017 - "The present study aimed to identify the therapeutic target of TSF in diabetic renal injuries through microarray-based gene expression profiling and establish its underlying mechanism. " 10/11/2011 - "This study showed a considerable burden for TSFs mainly due to associated injuries and increased lifelong RRM in patients with TSF." 10/11/2011 - "Incidence of TSF and associated injuries were obtained from two population based studies and National Trauma Data Bank in Iran, while duration, and relative risk of mortality (RRM) were obtained from WHO data and the literature. "
4.	Body Weight (Weight, Body) 01/01/2022 - "After 3 months of dietary guidance with nighttime snacking in the observation group, the dry body weight BMI, grip strength, TSF, L3-SMI, and CHE scores all increased, compared with the baseline data, while the Child-Pugh score decreased compared with the baseline level (all p < 0.05). " 01/01/2022 - "However, no statistically significant difference existed between the intervention group and the control group in terms of body weight, TSF, TP or ALB (P > 0.05). " 01/01/2021 - "In the first 48 h of hospitalization, anthropometric (body weight, height, mid-upper arm circumference - MUAC, tricipital skinfold - TSF, calculated body mass index - BMI and mid-arm muscle circumference - MAMC) and handgrip strength (HGS) assessments were performed. " 06/01/2020 - "Weight, body mass index (BMI), triceps skinfold thickness (TSF), fat mass (FM) and free fat mass (FFM) by bioelectrical impedance analysis were measured. " 01/01/2020 - "Height, weight, body mass index (BMI), triceps skinfold thickness (TSF), upper arm circumference (AC), leg circumference (LC), and other related parameters of human nutrition were measured. "
5.	Dyslipidemias (Dyslipidemia) 12/01/2016 - "However, whether TSF ameliorates dyslipidemia and liver injury associated with diabetes remains unclear. " 05/01/2016 - "According to the results, TSF attenuated hepatic steatosis and relieved dyslipidemia, its mechanism may be correlated with the regulation of macrophage activation and phenotypic switch." 05/01/2016 - "In this study, we investigated the effects and mechanism of Tangshen formula (TSF) on hepatic dyslipidemia and phenotypic switch of macrophage in db/db mice. "

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7.	Fibrinogen (Factor I)
8.	Fibrin
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Related Therapies and Procedures

1.	Therapeutics
2.	External Fixators
3.	Distraction Osteogenesis
4.	Decompression
5.	Osteotomy