22-hydroxycholesterol

Also Known As:

(22R)-22-hydroxycholesterol; 22(R)-hydroxycholesterol; 22(R)OH cholesterol; 22-hydroxycholesterol, (3beta,20R,22R)-isomer; 22-hydroxycholesterol, (3beta,20R,22S)-isomer; 22-hydroxycholesterol, (3beta,22R)-isomer; 22-hydroxycholesterol, (3beta,22S)-isomer; 22R-hydroxycholesterol; 22S-hydroxycholesterol; cholest-5-ene-3beta,22-diol

Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Papadopoulos, Vassilios: 4 articles (02/2021 - 12/2002)
2.	Lecanu, L: 3 articles (01/2012 - 01/2006)
3.	Papadopoulos, V: 3 articles (01/2012 - 01/2006)
4.	Greeson, Janet: 3 articles (03/2009 - 12/2002)
5.	Lecanu, Laurent: 2 articles (03/2009 - 01/2004)
6.	Han, Z: 2 articles (08/2007 - 01/2006)
7.	Yao, Z-X: 2 articles (08/2007 - 01/2006)
8.	Yao, Zhi-Xing: 2 articles (01/2004 - 12/2002)
9.	Galano, Melanie: 1 article (02/2021)
10.	Li, Lu: 1 article (02/2021)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2010 - "Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines." 09/01/2010 - "In this study, we report that T0901317 and 22(R)-hydroxycholesterol treatment inhibited the proliferation of different progression stages of LNCaP human prostate cancer cells, as well as different commonly used human cancer cell lines. " 02/18/2021 - "We generated STAR knockout (KO) MA-10 mouse tumor Leydig cells and showed that STAR KO cells failed to form progesterone in response to dibutyryl-cAMP and to TSPO drug ligands, but not to 22(R)-hydroxycholesterol, which is a membrane-permeable intermediate of the CYP11A1 reaction. " 03/16/2017 - "In the current study, we examined the effects of treatment of a mouse model of steroidogenesis, Y1-BS1 adrenocortical tumor cells with pregnenolone, 22(R)-Hydroxycholesterol [22(R)-diol] or hHDL3 on ROS production, phosphorylation status of p38 MAPK and cAMP response element-binding protein (CREB), CREB transcriptional activity and mRNA expression of StAR, CPY11A1/P450scc and antioxidant enzymes, superoxide dismutases [Cu,ZnSOD (SOD1), MnSOD (SOD2)], catalase (CAT) and glutathione peroxidase 1 (GPX1). "
2.	Prostatic Neoplasms (Prostate Cancer) 09/01/2010 - "In this study, we report that T0901317 and 22(R)-hydroxycholesterol treatment inhibited the proliferation of different progression stages of LNCaP human prostate cancer cells, as well as different commonly used human cancer cell lines. "
3.	Alzheimer Disease (Alzheimer's Disease) 03/01/2009 - "We identified 22R-hydroxycholesterol to be present in much lower levels in the hippocampus and frontal cortex of Alzheimer's disease than in tissue from age-matched controls. " 01/01/2004 - "In conclusion, these results suggest that spirost-5-en-3-ol naturally occurring derivatives of 22R-hydroxycholesterol might offer a new approach for Alzheimer's disease therapy." 01/01/2006 - "In Alzheimer's disease pathology neurosteroid biosynthesis is altered and a decrease in the intermediate 22R-hydroxycholesterol levels is observed. " 01/01/2012 - "Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties." 01/01/2012 - "The levels of translocator protein 18-kDa, mediating the import of cholesterol into mitochondria, correlated with increased pregnenolone formation and reduced levels of 22R-hydroxycholesterol in biopsies from Alzheimer's disease (AD), but not age-matched control, brains. "
4.	Teratocarcinoma 08/24/2007 - "Herein we report that 22R-hydroxycholesterol inhibits the proliferation of human Ntera2/D1 teratocarcinoma precursor cells (NT2) and induces these cells to differentiate into "neuron-like" or "astrocyte-like" cells. " 08/24/2007 - "22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells." 12/01/2002 - "22R-hydroxycholesterol was found to protect, in a dose-dependent manner, against Abeta-induced rat sympathetic nerve pheochromocytoma (PC12) and differentiated human Ntera2/D1 teratocarcinoma (NT2N) neuron cell death. " 08/24/2007 - "Recently, we have shown that 22R-hydroxycholesterol, a steroid intermediate in the pathway of pregnenolone formation from cholesterol, is present at lower levels in Alzheimer's disease (AD) hippocampus and frontal cortex tissue specimens than in age-matched controls, and that this substance protects against cell death induced by amyloid beta-peptide in both rat sympathetic nerve pheochromocytoma (PC12) and differentiated human Ntera2/D1 teratocarcinoma neurons. "
5.	Pheochromocytoma 12/01/2002 - "22R-hydroxycholesterol was found to protect, in a dose-dependent manner, against Abeta-induced rat sympathetic nerve pheochromocytoma (PC12) and differentiated human Ntera2/D1 teratocarcinoma (NT2N) neuron cell death. " 08/24/2007 - "Recently, we have shown that 22R-hydroxycholesterol, a steroid intermediate in the pathway of pregnenolone formation from cholesterol, is present at lower levels in Alzheimer's disease (AD) hippocampus and frontal cortex tissue specimens than in age-matched controls, and that this substance protects against cell death induced by amyloid beta-peptide in both rat sympathetic nerve pheochromocytoma (PC12) and differentiated human Ntera2/D1 teratocarcinoma neurons. "

Related Drugs and Biologics

1.	Pregnenolone
2.	Messenger RNA (mRNA)
3.	T0901317
4.	p38 Mitogen-Activated Protein Kinases
5.	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)
6.	Superoxides (Superoxide)
7.	Enzymes
8.	Catalase
9.	Antioxidants
10.	Glutathione Peroxidase GPX1

Related Therapies and Procedures

1.	Therapeutics