1,25-dihydroxyergocalciferol

RN given refers to (3beta,5Z,7E,22E)-isomer

Also Known As:

1 alpha,25-dihydroxyvitamin D2; 1,25-(OH)2D2; 1,25-dihydroxyergocalciferol, (1alpha,3beta,5Z,7E,22E)-isomer; 1,25-dihydroxyvitamin D2; PRI-1906

Networked: 16 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Secosteroids: 22
      - Vitamin D: 33265
        Ergocalciferols: 700
        1,25-dihydroxyergocalciferol: 16
    - Cholestanes
      - Sterols: 2245
        Ergocalciferols: 700
        1,25-dihydroxyergocalciferol: 16
      - Cholestenes
        Ergocalciferols: 700
        1,25-dihydroxyergocalciferol: 16
Lipids: 114793
- Membrane Lipids: 1591
  - Sterols: 2245
    - Ergocalciferols: 700
      - 1,25-dihydroxyergocalciferol: 16

Experts

1.	Kutner, Andrzej: 7 articles (01/2020 - 01/2002)
2.	Milczarek, Magdalena: 3 articles (01/2020 - 10/2008)
3.	Wietrzyk, Joanna: 3 articles (01/2020 - 10/2008)
4.	Chodyński, Michał: 2 articles (01/2020 - 10/2015)
5.	Pietraszek, Anita: 2 articles (01/2020 - 10/2015)
6.	Sakaki, Toshiyuki: 1 article (01/2020)
7.	Stachowicz-Suhs, Martyna: 1 article (01/2020)
8.	Yasuda, Kaori: 1 article (01/2020)
9.	Danilenko, Michael: 1 article (11/2016)
10.	Nachliely, Matan: 1 article (11/2016)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/18/2020 - "Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D2 Derivatives Modified at the Side Chain and the A-Ring."
2.	Rickets (Rachitis) 12/01/1999 - "On the basis of analysis of serum 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D2 and D3 concentrations, serum biochemical analysis, and urinary fractional clearance of electrolytes, the causes of rickets in our cat, were most compatible with a combination of excessive loss of phosphorus via the kidneys and deficient or abnormal hepatic 25-hydroxylation of vitamin D. "
3.	Neoplasms (Cancer) 10/20/2015 - "Analogs of 1,25-dihydroxyergocalciferol, modified in the side-chain and in the A-ring, were tested for their antiproliferative activity against a series of human cancer cell lines in vitro and in vivo toxicity. " 10/01/2008 - "PRI-1906 inhibited the tumor growth at doses 1 and 5 microg/kg per day, and PRI-2191 only at the dose 5 microg/kg per day. " 11/01/1999 - "Analogues PRI-1906, PRI-1907, PRI-1909, PRI-2191, PRI-2192, PRI-2193 and PRI-2194 were examined for their antiproliferative activity in vitro against a spectrum of various human cancer cell lines using the MTT technique. " 11/01/1993 - "Increased 1,25-(OH)2D2 concentration in a patient with malignancy-associated hypercalcemia receiving intravenous hyperalimentation inadvertently supplemented with vitamin D2."
4.	Leukemia 07/01/2012 - "Differentiation induced by 1α,25-dihydroxyvitamin D3 (1,25D) or its analogs PRI-1906 and PRI-2191 was enhanced by QVD to a varying degree, depending on the subtype of the leukemia. " 01/01/2002 - "PRI-1906, an analog of vitamin D2, and PRI-2191, an analog of vitamin D3 bind nuclear vitamin D receptor (nVDR) with substantially lower affinity than 1,25-dihydroxyvitamin D3 (1,25-D3), but have higher differentiation-inducing activity as estimated in HL-60 leukemia cellmodel. " 01/01/2005 - "We showed that pre-treatment with calcitriol or one of its side-chain-modified analogs PRI-1906 or PRI-2191 caused resistance of HL-60 promyelocytic leukemia cells to genistein-, doxorubicin-, cisplatin-, and taxol-induced apoptosis. " 01/01/2005 - "In this paper, we examined the effects of treatment with calcitriol or its side-chain-modified analogs, analog of Vitamin D2, coded PRI-1906, with monohomologated and unsaturated side-chain and the analog of Vitamin D3, coded PRI-2191, with (24R) hydroxyl group, and those of known cytostatics (genistein, etoposide, doxorubicin, cisplatin, and taxol) on the apoptosis of HL-60 promyelocytic leukemia cells. "
5.	Disease Progression 08/01/1994 - "The serum 24,25-(OH)2D2/25-OHD2 ratio was relatively constant throughout her clinical course, whereas the low serum 1,25-(OH)2D2/25-OHD2 ratio at admission gradually increased during admission, suggesting that the increase in serum 1,25-(OH)2D2 is due to increased production rather than decreased degradation. " 11/01/1993 - "This clinical course suggests that PTHrP, like PTH, stimulated 1 alpha-hydroxylase activity and produced excessive 1,25-(OH)2D2. "

Related Drugs and Biologics

1.	Vitamin D
2.	Phosphorus (Red Phosphorus)
3.	Electrolytes
4.	Calcifediol (Calcidiol)
5.	1 alpha,24-dihydroxyvitamin D3 (Tacalcitol)
6.	Calcitriol (Calcijex)
7.	Ergocalciferols (Ergocalciferol)
8.	24a-homo-1,15-dihydroxyergocalciferol
9.	Cholecalciferol (Vitamin D3)
10.	Vitamin D3 24-Hydroxylase

Related Therapies and Procedures

1.	Total Parenteral Nutrition