cortolone

RN given refers to (3alpha,5beta,20S)-isomer

Also Known As:

cortolone, (3alpha,5alpha,20S)-isomer; cortolone, (3alpha,5beta,20R)-isomer; 3 alpha,17 alpha,20 alpha,21-tetrahydroxy-5 beta- pregnan-11-one

Networked: 11 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - cortolone: 11

Experts

1.	Liu, Xiang: 3 articles (03/2020 - 01/2018)
2.	Liu, Xiaoyan: 3 articles (03/2020 - 01/2018)
3.	Sun, Wei: 3 articles (03/2020 - 01/2018)
4.	Zhang, Mingxin: 2 articles (03/2020 - 01/2018)
5.	Zhang, Yushi: 2 articles (03/2020 - 12/2019)
6.	Guo, Zhengguang: 2 articles (12/2019 - 01/2018)
7.	Sun, Haidan: 2 articles (12/2019 - 01/2018)
8.	Li, Hanzhong: 1 article (03/2020)
9.	Wang, Zhan: 1 article (12/2019)
10.	Zheng, Guoyang: 1 article (12/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1984 - "For instance, the ratio of androsterone to alpha-cortolone is particularly effective in identifying women with a high rate of recurrence, and this is largely independent of pathological stage and tumor grade." 03/01/2020 - "A metabolite panel consisting of cortolone, testosterone and L-2-aminoadipate adenylate was discovered to have good ability of distinguishing RCC from benign tumors, with an AUC of 0.868 for tenfold cross-validation and 0.873 for the validation group. " 12/05/2019 - "The panel of α-CEHC, β-cortolone, deoxyinosine, flunisolide, 11b,17a,21-trihydroxypreg-nenolone and glycerol tripropanoate could distinguish the patients with cancer from the HCs (the AUC was 0.950) and the external validation also displayed a good predictive ability (the AUC was 0.867). " 03/15/2023 - "Eleven steroids (5-pregnenetriol, dehydroepiandrosterone, cortisone, cortisol, α-cortolone, tetrahydro-11-deoxycortisol, etiocholanolone, pregnenolone, pregnanetriol, pregnanediol, and 5-pregnenediol) were quantified by LC-MS/MS in 24-h urine samples from 352 patients with adrenal tumor (281 ACA, 71 ACC). "
2.	Obesity 04/01/2023 - "In pre-adolescent children with obesity, α-cortol and especially α-cortolone appeared to be excreted more abundantly than β-cortol or β-cortolone. " 03/01/1999 - "There was a significant reduction in the urinary tetrahydrocortisol (THF) +/- 5alpha-THF/tetrahydrocortisone (THE) and the cortol/cortolone ratio in obesity (group A vs. C, 1.06 +/- 0.08 vs. 0.84 +/- 0.04 and 0.41 +/- 0.03 vs. 0.34 +/- 0.03, respectively; both P < 0.05). "
3.	Weight Loss (Weight Reduction) 05/01/2013 - "The ratio of cortisol to cortisone metabolites [(5α-tetrahydrocortisol (5αTHF) + tetrahydrocortisol (THF) + α-cortol)/(tetrahydrocortisone (THE) + α-cortolone)] and the ratio of 5α-THF/THF both decreased after stable weight loss, reflecting a downregulation of the net activities of 11β-HSD type 1 and 5α-reductase. "
4.	Hyperplasia 07/01/1977 - "The effect of aminoglutethimide (AG) 4 X 250 mg (670 mg/m2 daily by mouth) on the excretion of the free cortisol (radio-immunoassay) and of its metabolites THE, THF-allo THF, cortolone and beta-cortolone (gas chromatography on capillary column) was studied monthly during 3-5 months in four adolescents (one girl, three boys) aged 15.9-18 years with Cushing's syndrome due to bilateral adrenal hyperplasia, but without evidence of a pituitary tumour. "
5.	Hirsutism 01/01/1979 - "Urinary unconjugated cortisol, total 17-oxogenic steroids and cortisol metabolites (THF, allo-THF, THE, cortol and cortolone) were measured in 90 normal women and in 90 women with idiopathic hirsutism of comparable age group. "

Related Drugs and Biologics

1.	cortol
2.	Tetrahydrocortisone
3.	Tetrahydrocortisol
4.	Androsterone
5.	Hydrocortisone (Cortisol)
6.	Steroids
7.	Pregnanetriol
8.	Etiocholanolone
9.	Cortisone
10.	Testosterone (Sustanon)