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4'-phosphopantetheine
Also Known As:
PSH-4'-P; pantetheine-4'-phosphate; phosphopantetheine
Networked:
15
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Sulfhydryl Compounds: 4168
Pantetheine: 23
4'-phosphopantetheine: 15
Related Diseases
1.
Fatty Liver
05/25/1976 - "
On the 4'-phosphopantetheine content of chicken and rat liver fatty acid synthetases.
"
08/10/1972 - "
The effect of fasting on synthesis and 4'-phosphopantetheine exchange in rat liver fatty acid synthetase.
"
03/20/1968 - "
Incorporation of pantothenate-1-14C into pigeon liver fatty acid synthetase: 4'-phosphopantetheine, a prosthetic group of the multienzyme complex.
"
10/15/1986 - "
The 4'-phosphopantetheine of chicken liver fatty acid synthase was specifically labeled with the fluorescent substrate analog coenzyme A 6-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]aminohexanoate at low salt concentrations.
"
01/29/1982 - "
Role of cysteine and 4'-phosphopantetheine in the inactivation of pigeon liver fatty acid synthetase by S-(4-bromo-2,3-dioxobutyl)-coenzyme A.
"
2.
Atherosclerotic Plaque (Atheroma)
01/01/2022 - "
4'-phosphopantetheine acts as a potential antioxidant to limit atherosclerotic plaque formation by inhibiting ROS generation.
"
3.
Avian Malaria
05/01/1975 - "
The extracellular development in vitro of the avian malaria Plasmodium lophurae is favored by addition to the medium of coenzyme A at 0.05 mM. Coenzyme A can be replaced by dephospho-coenzyme A and to some extent by phosphopantetheine, but not by phosphopantothenoylcysteine or by phosphopantothenic acid.
"
4.
Dehydration (Water Stress)
04/15/1987 - "
Reactivation of the NADP-inhibited 3-ketoacyl-enzyme, by exposure to NADPH, is paralleled by reduction and dehydration of the 3-ketoacyl moiety to a saturated acyl moiety without accumulation of either the 3-hydroxy or 2-enoyl acyl-enzyme intermediates, indicating that once the 4'-phosphopantetheine engages the ketoacyl moiety in the ketoreductase domain, subsequent reactions occur very rapidly.
"
5.
Avitaminosis (Vitamin Deficiency)
01/01/1987 - "
Although the animals did not show symptoms of vitamin deficiency, the concentrations of total and free CoA (analyzed with 2-oxoglutarate dehydrogenase), the levels of CoA, dephospho-CoA and 4'-phosphopantetheine (assayed together in the N-acetylation reaction) were decreased.
"
Related Drugs and Biologics
1.
Acids
2.
Ligases (Synthetase)
3.
Cysteine (L-Cysteine)
4.
Coenzyme A (CoA)
5.
Proteins (Proteins, Gene)
6.
NADP (NADPH)
7.
Enzymes
8.
Serine (L-Serine)
9.
Salts
10.
Protein Precursors