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epitiostanol
used in therapy of advanced breast cancer; structure
Also Known As:
10275-S; 2 alpha,3 alpha-epithio-5 alpha-androstan-17 beta-ol; Thiodrol; epithiostanol; androstan-17-ol, 2,3-epithio-, (2 alpha,3 alpha,5 alpha,17 beta)-
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Androstanes: 11
Androstanols
epitiostanol: 5
Related Diseases
1.
Neoplasms (Cancer)
04/01/1995 - "
The incidence of apoptosis revealed by the nick end labeling method reached its maximum, about threefold the control level, on the 3rd day of epitiostanol treatment compared with control tumors (P < 0.01).
"
04/01/1995 - "
BrdU-labeled apoptotic bodies were detected in the tumors on the 3rd day in epitiostanol-treated rats that received a 6-hr bolus of BrdU before sacrifice.(ABSTRACT TRUNCATED AT 250 WORDS)
"
12/01/1977 - "
A comparison of these findings to those obtained with earlier generations suggests that TPDMT-4 tumors became less sensitive to the antitumor effect of epitiostanol and were able to grow at lower hormone levels with succeeding generations.
"
05/01/1976 - "
Tumors regressed immediately after ovariectomy or after the start of 10275-S treatment and after approximately the 10th day of testosterone treatment.
"
08/01/1983 - "
Tamoxifen (TAM), with estrogenic activity, and epithiostanol (EPI) and testosterone propionate, with androgenic activity, which all caused TPDMT-4 tumors to regress, were compared for antitumor potency against the new subline by 3 s.c.
"
2.
Breast Neoplasms (Breast Cancer)
07/01/1988 - "
[A case of advanced breast cancer successfully treated with combined tamoxifen and epitiostanol].
"
04/01/1995 - "
To elucidate the relationship of estrogen-depleted condition to apoptosis and tumor regression, 7,12-dimethylbenz[a]anthracene-induced mammary cancers of Sprague-Dawley rats were ovariectomized or treated with the anti-estrogenic agent epitiostanol after which proliferative activity and the incidence of apoptosis were investigated using the nick end labeling method, agarose gel electrophoresis of DNA, electron microscopy, the BrdU-labeling method and mitotic count.
"
Related Drugs and Biologics
1.
Tamoxifen
2.
Testosterone Propionate
3.
Testosterone (Sustanon)
4.
Steroids
5.
Sepharose (Agarose)
6.
Progesterone
7.
Hormones (Hormone)
8.
Estrogens (Estrogen)
9.
DNA (Deoxyribonucleic Acid)
10.
Bromodeoxyuridine (BrdU)
Related Therapies and Procedures
1.
Ovariectomy (Oophorectomy)
2.
Injections