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alovudine

Also Known As:

(18)FLT cpd; (18F)3'-deoxy-3'-fluorothymidine; (18F)FLT; 1-(3'-fluoro-3'-deoxy-beta-D-erythropentofuranosyl)thymine; 18F-FLT; 3'-(F-18)fluoro-3'-deoxythymidine; 3'-deoxy-3'-(18F)fluorothymidine; 3'-deoxy-3'-fluorothymidine; 3'-fluoro-2',3'-dideoxythymidine; 3'-fluoro-3'-deoxythymidine; 3'-fluorothymidine; FDDT

Networked: 150 relevant articles (5 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 713
  - Deoxyribonucleosides: 25
    - Dideoxynucleosides: 27
      - alovudine: 150

Experts

1.	Aboagye, Eric O: 9 articles (01/2014 - 03/2005)
2.	Krohn, Kenneth A: 8 articles (05/2015 - 05/2004)
3.	Buck, Andreas K: 7 articles (07/2014 - 09/2003)
4.	Nishiyama, Yoshihiro: 6 articles (05/2015 - 10/2007)
5.	Yamamoto, Yuka: 6 articles (05/2015 - 10/2007)
6.	Schwartz, Jeffrey L: 5 articles (05/2015 - 05/2004)
7.	Jacobs, Andreas H: 5 articles (01/2014 - 12/2005)
8.	Elsinga, Philip H: 5 articles (01/2011 - 02/2004)
9.	Jager, Pieter L: 5 articles (12/2009 - 02/2004)
10.	Grierson, John R: 5 articles (01/2007 - 05/2004)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2005 - "The rate constant for the metabolite-corrected net irreversible uptake of [18F]FLT (Ki) ranged from 0.6 to 10.4 x 10(-4) and from 0 to 0.6 x 10(-4) mL plasma cleared/s/mL tissue in tumor (29 regions, 15 patients) and normal tissues, respectively. " 07/01/2014 - "Further studies are needed to determine the optimal timing of 18F-FLT PET/CT imaging in the course of cancer therapies or at the conclusion of therapy." 01/01/2012 - "The aim of the study was to use [18F]FLT positron emission tomography (PET) to study non-invasively early anti-proliferative effects of the experimental chemotherapeutic agent TP202377 in both sensitive and resistant tumors. " 02/01/2005 - "Kinetic modeling of 3'-deoxy-3'-fluorothymidine in somatic tumors: mathematical studies." 10/01/2004 - "In the biodistribution study, considerable uptake of 18F-FLT was observed in both tumor types. "
2.	Glioblastoma (Glioblastoma Multiforme) 10/01/2014 - "Assessment of early therapy response with 18F-FLT PET in glioblastoma multiforme." 01/01/2012 - "Cell uptake of 18F-FLT and 125I-IdUrd was studied in 2 human breast, 2 colon cancer and 2 glioblastoma lines. " 12/01/2005 - "Uptake ratios of 18F-FLT were higher in glioblastomas than in astrocytomas (P<0.01). " 01/01/2013 - "Early assessment of the efficacy of temozolomide chemotherapy in experimental glioblastoma using [18F]FLT-PET imaging."
3.	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/01/2013 - "[18F]FLT is superior to [18F]FDG for predicting early response to antiproliferative treatment in high-grade lymphoma in a dose-dependent manner." 05/01/2011 - "Predictive value of initial 18F-FLT uptake in patients with aggressive non-Hodgkin lymphoma receiving R-CHOP treatment."
4.	Carcinoid Tumor (Carcinoid) 01/01/2014 - "Everolimus was effective in vitro and in vivo in human xenografts lung carcinoid NETs and especially early 18F-FLT uptake predicted subsequent tumor growth. "
5.	Breast Neoplasms (Breast Cancer) 10/01/2012 - "She entered a clinical 18F-FLT PET trial in our hospital to differentiate malignant breast tumors from benign ones. " 01/01/2013 - "Calibration test of PET scanners in a multi-centre clinical trial on breast cancer therapy monitoring using 18F-FLT." 01/01/2012 - "FdUrd enhanced 18F-FLT cellular inflow in 2 breast cancer lines by factors of 1.8 and 1.6, respectively, while outflow persisted at a slightly lower rate. " 09/01/2007 - "3'-deoxy-3'-[18F]fluorothymidine positron emission tomography ([18F]FLT-PET) has been developed for imaging cell proliferation and findings correlate strongly with the Ki-67 labelling index in breast cancer. " 11/01/2005 - "We conclude that [18F]FLT-positron emission tomography is a promising clinical tool for imaging cellular proliferation in breast cancer, and is most predictive when analyzed by graphical and spectral methods."

Related Drugs and Biologics

1.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)
2.	everolimus
3.	temozolomide (Temodar)
4.	Thymidine
5.	Glucose (Dextrose)
6.	Zidovudine (Retrovir)
7.	Biological Markers (Surrogate Marker)
8.	Tyrosine (L-Tyrosine)
9.	Isoflurane
10.	Deoxyglucose (2 Deoxy D glucose)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Radiotherapy
4.	Anesthesia
5.	Aftercare (After-Treatment)