2,3-oxidosqualene

an oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer

Also Known As:

2,3-EDSQ; 2,3-epoxy-2,3-dihydrosqualene; 2,3-oxidosqualene, (R)-isomer; 2,3-oxidosqualene, (R-(all-E))-isomer; 2,3-oxidosqualene, (S)-isomer; 2,3-oxidosqualene, (S-(all-E))-isomer; 2,3-oxidosqualene, (all-E)-(+-)-isomer; squalene monohydroperoxide; squalene peroxide; squalene-2,3-epoxide; squalene-2,3-oxide

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Squalene: 350
        2,3-oxidosqualene: 11
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Polyenes: 164
        Squalene: 350
        2,3-oxidosqualene: 11

Experts

1.	Amalric, Nicolas: 1 article (04/2016)
2.	Bastien, Philippe: 1 article (04/2016)
3.	Breton, Lionel: 1 article (04/2016)
4.	El Rawadi, Charles: 1 article (04/2016)
5.	Jourdain, Roland: 1 article (04/2016)
6.	Moga, Alain: 1 article (04/2016)
7.	Pouradier, Florence: 1 article (04/2016)
8.	Souverain, Luc: 1 article (04/2016)
9.	Vingler, Philippe: 1 article (04/2016)
10.	Dong, Rui-Hong: 1 article (12/2015)

Related Diseases

1.	Erythema 12/01/1999 - "The present study examines the cumulative effects of sub-erythema application of squalene-monohydroperoxide (Sq-OOH), the initial products of UV-peroxidated squalene, to the skin of hairless mice. "
2.	Dandruff 04/01/2016 - "Squalene, a major sebum component, was significantly more peroxidized in dandruff-affected scalps, resulting in significantly higher ratios of squalene monohydroperoxide (SQOOH)/squalene. " 04/01/2016 - "Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in dandruff condition." 02/15/2023 - "Recently, squalene monohydroperoxide and malondialdehyde were established as biomarkers of dandruff-afflicted scalp, highlighting the role of sebum lipoperoxidation in the triggering and maintenance of dandruff, although its mechanism of action is unknown. "
3.	Tetraploidy 01/01/2023 - "The transcriptome analysis showed that 2,3-OXIDOSQUALENE CYCLASEs (OSCs) involved in phytosterol biosynthesis are upregulated in the diploid species, while the expression of OSCs contributing to ginsenoside biosynthesis is higher in the tetraploid species. "
4.	Hyperpigmentation 09/01/2009 - "Furthermore, we found that topical application of squalene peroxide induced skin hyperpigmentation through increasing prostaglandin E(2) release from keratinocytes in guinea pigs. "
5.	Sunburn 05/01/1984 - "To clarify the role of squalene peroxide in the occurrence of skin damage from sunburn, the optimum condition of squalene peroxidation and the effect of squalene peroxide on cutaneous tissue were examined. "

Related Drugs and Biologics

1.	Squalene
2.	Phytosterols (Plant Sterols)
3.	Squalene Monooxygenase (Squalene Epoxidase)
4.	Ginsenosides
5.	Biomarkers (Surrogate Marker)
6.	Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)
7.	Prostaglandins
8.	Mevalonic Acid (Mevalonate)
9.	Malondialdehyde (Propanedial)
10.	Lipids