oleuropein

08/22/2022 - "This study investigated the functional role of oleuropein in a 2,4-dinitrochlorobenzene-induced AD-like mouse model, with a focus on allergic inflammation. "
01/01/2021 - "The present study aimed to further clarify the mechanism by which oleuropein exerts effects on inflammation in vitro and in vivo. "
07/01/2023 - "Oleuropein reduces LPS-induced inflammation via stimulating M2 macrophage polarization."
02/01/2022 - "Here, we assessed the ability of oleuropein to attenuate this inflammation in ARPE-19 cells. "
02/01/2022 - "Oleuropein Protects Human Retinal Pigment Epithelium Cells from IL-1β-Induced Inflammation by Blocking MAPK/NF-κB Signaling Pathways."

09/01/2022 - "Previous studies have revealed that oleuropein (OL) can inhibit the EMT alterations and migration of cancer cells. "
01/01/2022 - "Based on these findings, it can be concluded that oleuropein can function as a promising chemopreventive and chemotherapeutic agent against cancer, but its more detailed anticancer effects and underlying mechanisms need to be further validated in future preclinical as well as clinical studies."
07/19/2019 - "The present study aimed to transfer oleuropein into cancer cells using synthetic paramagnetic nanoparticles and study their effect on the AGS (ATCC® CRL1739™) cell line. "
07/08/2017 - "Recently, several studies have demonstrated that oleuropein inhibits proliferation and induces apoptosis in different cancer cell lines. "
10/17/2023 - "Furthermore, oleuropein reduced the expression of the anti-apoptotic genes Bcl-2 and Mcl1, whereas it elevated the expression of the pro-apoptotic Bid, Fas, and TNFRSF10B genes and the p53 tumor suppressor. "

06/22/2021 - "Oleuropein Ameliorates Advanced Stage of Type 2 Diabetes in db/db Mice by Regulating Gut Microbiota."
08/05/2015 - "In this study, we investigated the effects of the oleuropein-containing supplement OPIACE, whose oleuropein content exceeds 35% (w/w), on the diabetic phenotypes in type 2 diabetes model Tsumura Suzuki Obese Diabetes (TSOD) mouse. "
08/05/2015 - "The results suggest that oleuropein suppresses the progression of type 2 diabetes and diabetes-related behavioral abnormality over the long-term. "
11/01/2017 - "These results suggest the possibility of oleuropein to be effective for type 2 diabetes by reducing insulin resistance in skeletal muscles."
07/01/2014 - "The study aimed at examining the role of oxidative stress in cadioprotective effects of oleuropein in a rat model of simultaneous type 2 diabetes and renal hypertension. "

01/01/2023 - "Olive Leaves Extract and Oleuropein Improve Insulin Sensitivity in 3T3-L1 Cells and in High-Fat Diet-Treated Rats via PI3K/AkT Signaling Pathway."
04/01/2022 - "While many experimental investigations have examined the mechanisms by which oleuropein improves insulin resistance and diabetes, much of these investigations have been carried out in either muscle cell lines or in vivo models two scenarios with many drawbacks. "
04/01/2022 - "Oleuropein, the main constituent of olive fruit and leaves, has been reported to protect against insulin resistance and diabetes. "
01/01/2022 - "Oleuropein reduced insulin resistance, spatial learning, and memory ability in diabetic rats. "
11/01/2017 - "Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT4."

09/01/2010 - "Oleuropein is also reported to have protective effects against non-alcoholic fatty liver disease (NAFLD) in vivo. "
12/08/2018 - "Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender."
02/11/2022 - "Copper-catalyzed dicarbonyl stress in NAFLD mice: protective effects of Oleuropein treatment on liver damage."
10/14/2014 - "In addition, we provide data collected in our laboratory on the role of oleuropein in counteracting lipid accumulation in a mouse model of non-alcoholic fatty liver disease. "
09/01/2010 - "The (putative) candidate TFs that bound to the promoters of the genes regulated at least threefold (both up and down) by oleuropein were implicated in the lipogenesis, inflammation, insulin resistance, fibrosis, and cell proliferation and differentiation, which implies that the mechanisms that underlie the beneficial effects of oleuropein on NAFLD may be multifactorial."