normeperidine

01/01/2000 - "Renal failure significantly increases the plasma half-life of normeperidine. "
05/01/1997 - "However, the sole active metabolite, normeperidine, is a central nervous system excitatory agent and has the ability to cause seizures, especially in patients with renal failure. "
12/01/1989 - "Norpethidine induced myoclonus in a patient with renal failure."
06/01/1977 - "Normeperidine levels were 0.05 to 0.28 microng/ml in the cancer patients and 0.13 to 0.36 in the renal failure patients. "
03/01/1992 - "This is a report of the lethal effects of normeperidine in a patient with renal failure who had abused meperidine."

03/11/2014 - "In patients with impaired renal and liver function, and those who need long-term pain control, pethidine may cause excitatory central nervous system (CNS) effects through its neurotoxic metabolite, norpethidine, resulting in irritability and seizure attack. "
03/01/1986 - "Preliminary results suggest that postpartum pain medication with meperidine results in considerable levels of both meperidine and its active metabolite, normeperidine, in breast milk."
04/01/2014 - "Clearance of meperidine and its metabolite normeperidine in hemodialysis patients with chronic noncancer pain."
04/01/2014 - "Hemodialysis can efficiently remove meperidine and its active metabolite, normeperidine, in uremic patients receiving long-term meperidine therapy for chronic noncancer pain."

10/01/1976 - "There is, however, a gradual accumulation of normeperidine in plasma after repeated doses as determined in samples from cancer patients. "
06/01/1977 - "Normeperidine levels were 0.05 to 0.28 microng/ml in the cancer patients and 0.13 to 0.36 in the renal failure patients. "
03/01/1994 - "Normeperidine is eliminated by the kidneys and accumulates in patients with renal insufficiency, sickle cell disease, and cancer. "
06/01/1977 - "The ratio of normeperidine to meperidine levels was always higher in the renal failure patients than in the cancer patients. "
06/01/1977 - "Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer."

03/01/1994 - "Normeperidine is eliminated by the kidneys and accumulates in patients with renal insufficiency, sickle cell disease, and cancer. "

08/01/2000 - "Seizures due to norpethidine toxicity."
05/01/1997 - "However, the sole active metabolite, normeperidine, is a central nervous system excitatory agent and has the ability to cause seizures, especially in patients with renal failure. "
01/01/1997 - "Norpethidine produced dose-related increases in the incidence of seizures, myoclonic jerks and shivering. "
11/01/1990 - "We have reported a case of normeperidine-induced seizures in a patient with hereditary coproporphyria. "
11/01/1990 - "Normeperidine-induced seizures in hereditary coproporphyria."