parthenolide

a germacrane type of sesquiterpene lactone; found in Tanacetum parthenium and Magnolia grandiflora L; has antineoplastic activity; RN given refers to cpd without isomeric designation; structure

Also Known As:

Networked: 408 relevant articles (41 outcomes, 85 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Crooks, Peter A: 12 articles (01/2018 - 06/2007)
2.	Jordan, Craig T: 12 articles (01/2017 - 06/2005)
3.	Li, Yan: 10 articles (12/2021 - 03/2006)
4.	Sweeney, Christopher J: 10 articles (10/2018 - 08/2004)
5.	Kim, In Hee: 9 articles (10/2019 - 07/2012)
6.	Lee, Soo Teik: 9 articles (10/2019 - 07/2012)
7.	Nakshatri, Harikrishna: 9 articles (05/2011 - 08/2004)
8.	Kim, Seong Hun: 8 articles (01/2017 - 07/2012)
9.	Chen, Yue: 7 articles (01/2020 - 07/2014)
10.	Kim, Sang-Wook: 7 articles (12/2017 - 10/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "SIGNIFICANCE: This study reveals novel inactivation mechanisms and tumor-suppressive roles of ARID1A in SCC and proposes parthenolide as an effective treatment for patients with SCC with low ARID1A expression." 05/23/2023 - "This study evaluated in vitro parthenolide efficacy in lymphoid neoplasms. " 09/19/2017 - "In this study, parthenolide (PTL) was used as an example to explore the anti-tumor effect of natural molecules and their common mechanism. " 02/01/2013 - "The aim of the present study was to investigate the effects of parthenolide on heterogeneous cancer cell populations from anchorage-independent melanospheres. " 10/01/2012 - "It includes parthenolide, a highly cytotoxic SL that is being tested in clinical trials as an anti-cancer agent. "
2.	Inflammation (Inflammations) 01/01/2020 - "Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner." 01/01/2015 - "These data will be helpful for future investigations into the effects of parthenolide on inflammation. " 01/01/2023 - "Moreover, using bioinformatics methods, we identify 15-deoxy-Δ12,14-PGJ2 and parthenolide as inhibitors of caspase-4-mediated inflammation and vesicle secretion, indicating new therapeutic potential of these anti-inflammatory drugs." 02/01/2011 - "Parthenolide, an inhibitor of the NFκB pathway, counteracted PI-induced increased inflammation and decreased glyceroneogenesis. " 12/01/2002 - "This finding raises the potential to develop parthenolide to treat IL-4-mediated allergic-like inflammation."
3.	Melanoma (Melanoma, Malignant) 02/01/2010 - "The aim of the study was to examine anticancer effects of parthenolide in melanoma cells in vitro. " 10/01/2023 - "Parthenolide induces ER stress-dependent apoptosis in melanoma cells." 02/23/2016 - "The mode of the response to parthenolide is bound to the molecular characteristics of melanoma cells, particularly to the basal MITF-M expression level but other cell-autonomous differences such as NF-κB activity and MCL-1 level might also contribute. " 02/23/2016 - "Parthenolide induces diverse effects in melanoma cells, from death to senescence. " 02/23/2016 - "Our results obtained in patient-derived melanoma cell populations indicate that parthenolide efficiently decreases the MITF-M level. "
4.	Carcinogenesis 03/01/2018 - "Therefore, the present study is aimed at investigating the chemopreventive potential of parthenolide in DMBA-induced hamster buccal pouch carcinogenesis. " 01/01/2014 - "Dimethylaminoparthenolide, a water soluble parthenolide, suppresses lung tumorigenesis through down-regulating the STAT3 signaling pathway." 03/01/2018 - "The apoptotic gene p53 and antiapoptotic gene Bcl-2 were significantly down regulated; whereas, pro-apoptotic gene Bax was up regulated in group III hamsters compared to group II. The results of the present study suggest that parthenolide have potent chemopreventive, antioxidant, and apoptotic effect in DMBA-induced oral carcinogenesis." 01/01/2014 - "In the present study, we showed, using an in vitro model of lung tumorigenesis, that dimethylamino-parthenolide (DMAPT), a water soluble parthenolide analog, selectively inhibited the growth and survival of premalignant and malignant cells with minimal effects on parental immortalized cells. " 03/01/2018 - "Parthenolide attenuates 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis."
5.	Neuroinflammatory Diseases 03/01/2017 - "Results of this study corroborate the involvement of neuroinflammation in the development of behavioural and neurochemical deficits in diabetic animals and point towards the therapeutic potential of parthenolide in diabetes-induced alteration of learning, memory and anxiety behaviour." 11/01/2009 - "The objective of this study was to test the hypothesis that parthenolide suppresses ischemia-induced neuroinflammation in the MCAO model of adult rat. " 07/01/2023 - "Parthenolide alleviates microglia-mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder." 11/01/2009 - "Parthenolide inhibits neuroinflammation induced by cerebral ischemia and promotes neurogenesis in the ischemic striatum. " 11/01/2009 - "[Parthenolide inhibits neuroinflammation and promotes neurogenesis in the ischemic striatum following transient middle cerebral artery occlusion in the adult rat brain]."

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Lactones
3.	Sesquiterpenes
4.	Paclitaxel (Taxol)
5.	Curcumin
6.	Inflammasomes
7.	Proteins (Proteins, Gene)
8.	Transcription Factors (Transcription Factor)
9.	Liposomes (Liposome)
10.	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Radiotherapy
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)