kaurene

01/01/2013 - "Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells."

01/01/2019 - "Kaurene is known as a potent biological agent for the treatment of cancer patients. "
01/01/2013 - "Studies have shown that classes of kaurene diterpene have anti-tumor activity related to their ability to induce apoptosis. "
12/08/2006 - "Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitro."
11/01/2010 - "Rabdosia rubescens extract (RRE) contains terpenoids and flavonoids, but the most active ingredient within the extract attributed to the inhibition of cancer is the kaurene diterpene, oridonin. "
01/01/2019 - "Combined oridonin (ORI), a natural and safe kaurene diterpenoid isolated from Rabdosia rubescens, and cetuximab (Cet), an anti-EGFR monoclonal antibody, have been reported to exert synergistic anti-tumor effects against laryngeal squamous cell carcinoma (LSCC) both in vitro and in vivo by our group. "

10/01/2004 - "Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway."

01/01/2013 - "Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine proteases."

01/01/2019 - "Combined oridonin (ORI), a natural and safe kaurene diterpenoid isolated from Rabdosia rubescens, and cetuximab (Cet), an anti-EGFR monoclonal antibody, have been reported to exert synergistic anti-tumor effects against laryngeal squamous cell carcinoma (LSCC) both in vitro and in vivo by our group. "