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isopropylmethanesulfonate

RN given refers to unlabeled cpd

Also Known As:

isopropyl methanesulfonate; isopropylmethanesulfonate, 3H-labeled; methanesulfonic acid 1-methylethyl ester

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Alkanesulfonic Acids
        Alkanesulfonates: 9
        Mesylates: 334
        isopropylmethanesulfonate: 5
- Sulfur Compounds: 278
  - Sulfur Acids
    - Sulfonic Acids: 1605
      - Alkanesulfonic Acids
        Alkanesulfonates: 9
        Mesylates: 334
        isopropylmethanesulfonate: 5

Related Diseases

1.	Lymphoma (Lymphomas) 10/01/1986 - "Rapid induction of thymic lymphomas by isopropyl methanesulfonate: a preliminary report." 03/01/1989 - "Inducibility of thymic lymphomas in female Hsd: (ICR)BR mice following subcutaneous injection of ethyl- and isopropyl methanesulfonate." 07/01/1987 - "Induction of thymic lymphomas and squamous cell carcinomas following topic application of isopropyl methanesulfonate to female Hsd:(ICR)BR mice." 03/01/1989 - "Isopropyl methanesulfonate (IMS), a direct-acting SN1 alkylating agent, induced thymic lymphomas in 29 of 30 female Hsd: (ICR)BR mice by the 139th day following once a week subcutaneous injections at a dose of 10 mumol/mouse. "
2.	Xeroderma Pigmentosum (Kaposi's Disease) 01/01/1982 - "Excision repair of DNA in normal and xeroderma pigmentosum complementation group A fibroblasts were examined following treatment with methyl-, ethyl-, and isopropyl methanesulfonate. "
3.	Neoplasms (Cancer) 10/01/1986 - "The direct-acting SN1 alkylating agent isopropyl methanesulfonate (IMS) was carcinogenic by subcutaneous injection in female Hsd:(ICR)BR mice, causing thymic lymphoid neoplasms within 7 months in at least 20 of 32 treated mice. "
4.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/1980 - "These differences between ethyl methanesulfonate and triethylenemelamine on one hand and isopropyl methanesulfonate on the other were hypothesized to be a function of the types of chromosomal lesions present at the time of repair activity and whether or not chromosomal aberrations were already fixed at the time of postfertilization pronuclear DNA synthesis."
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 07/01/1987 - "Induction of thymic lymphomas and squamous cell carcinomas following topic application of isopropyl methanesulfonate to female Hsd:(ICR)BR mice."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Alkylating Agents
3.	Triethylenemelamine (Tretamine)
4.	Ethyl Methanesulfonate

Related Therapies and Procedures

1.	Subcutaneous Injections