cinobufagin

04/06/2023 - "Cinobufagin has inhibitory effects on various tumors, but there are few studies on gynecological tumors. "
08/23/2021 - "As elevated oxidative pressure is shared by most cancer cells that renders them sensitive to further oxidative insult, these studies suggest that nontoxic doses of cinobufagin can be used to exploit a cancer vulnerability for induction of cancer-specific cytotoxicity."
10/01/2019 - "Many studies have shown that cinobufagin has antitumor effects against many cancers. "
04/12/2013 - "Several studies have suggested that cinobufagin has potent anti-cancer effects. "
09/01/2023 - "Cinobufagin has the potential to be further developed as a new drug against cancer."

01/01/2019 - "Cinobufagin is one of the active ingredients in the anticancer Chinese medicine called Chan Su, which was demonstrated to be an effective treatment for gastric cancer. "
01/01/2019 - "The aim of the present study was to investigate the relationship between cinobufagin, autophagy and apoptosis in gastric cancer. "
01/01/2019 - "Altogether, these data suggest that inhibition of autophagy enhances the anticancer action of cinobufagin through increased apoptosis of gastric cancer cells. "
12/01/2021 - "In this study, a pH-responsive liposome (Liposome-PEO, LP) loaded with apatinib (AP) and cinobufagin (CS-1) was used for combinational therapy against gastric cancer after coating with a hybrid membrane (R/C). "

01/01/2023 - "Effects of Cinobufagin on the Proliferation, Migration, and Invasion of H1299 Lung Cancer Cells."
09/13/2020 - "Cinobufagin sensitively attenuates cell viability and induces apoptosis in LEF1 expressing melanoma cells compared to LEF1-low expressing lung cancer cells. "
01/01/2021 - "In the present study, a targeted delivery and smart responsive polydopamine (PDA)-based nanomedicine for delivering cinobufagin was rationally designed to improve the anticancer efficacy of the compound for the treatment of lung cancer. "
01/01/2018 - "Using thalidomide combined with cinobufagin to treat patients with lung cancer cachexia will significantly improve their nutritional status and quality of life. "
01/01/2018 - "To discuss and assess the clinical value of treating lung cancer cachexia with thalidomide combined with cinobufagin.s. "

02/14/2017 - "To investigate the mechanism of cinobufagin-reduced cancer pain in mouse cancer pain model and in vitro cell co-culture system. "
01/01/2013 - "Cinobufagin significantly relieved cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue. "
01/01/2013 - "To investigate the changes in thermal and mechanical hyperalgesia in paw cancer pain in mice and the action mechanism of cinobufagin using a paw cancer pain model. "
01/01/2013 - "Cinobufagin has been widely used in the treatment of carcinoma and plays an important role in the relief of cancer pain. "
01/01/2013 - "A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Local β -Endorphin Expression In Vivo."

01/01/2014 - "Cinobufagin and resibufogenin are two major effective bufadienolides of Chan su (toad venom), which is a Chinese medicine obtained from the skin venom gland of toads and is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers. "