galactocerebroside

01/31/1992 - "In control samples, the specific activity (nmol/mg prot./h) for HMGal is higher than for the natural substrate, galactocerebroside, and is severely deficient in the twitcher mouse and in patients with Krabbe disease. "
12/15/1982 - "An accumulation of galactocerebroside in kidney from mouse globoid cell leukodystrophy (twitcher)."
07/01/1991 - "The progression and characteristics of magnetic resonance imaging (MRI) and computed tomographic (CT) findings in 3 patients with infantile Krabbe disease (i.e., globoid cell leukodystrophy or galactocerebroside beta-galactosidase deficiency) are reported. "
01/01/1975 - "A Japanese boy was diagnosed as globoid cell leukodystrophy on the basis of a marked decrease in the galactocerebroside beta-galactosidase activity in the leukocytes and the serum when one year and two months old. "
08/01/2013 - "Globoid cell leukodystrophy (GLD) is a common neurodegenerative lysosomal storage disorder caused by a deficiency in galactocerebrosidase (GALC), an enzyme that cleaves galactocerebroside during myelination. "

07/01/1986 - "Ultrastructural study of central nervous system demyelination in galactocerebroside sensitized rabbits."
04/01/1979 - "In vivo demyelination induced by intraneural injection of anti-galactocerebroside serum: a morphologic study."
12/20/2005 - "Failure in catalyzing the degradation of its major substrate, galactocerebroside, in oligodendrocytes (OLs) and Schwann cells leads to death of these myelinating cells, progressive demyelination, and early demise of GLD patients. "
08/01/1998 - "The average number of mitochondria per unit area of axon within axons of normal cat optic nerve and optic nerve in which demyelination had been induced with anti-galactocerebroside (GC) was determined using transmission electron microscopy. "
08/01/1993 - "The possibility that HNK-1 antibody might identify oligodendrocyte precursors in vivo was investigated using a combined immunocytochemical and ultrastructural analysis of remyelination in the cat optic nerve after demyelination induced by local injection of antiserum against galactocerebroside. "

09/01/1988 - "A study on demyelinating effect of galactocerebroside in experimental allergic encephalomyelitis."
09/01/1988 - "An experimental allergic encephalomyelitis was induced by bovine myelin basic protein (MBP) and bovine galactocerebroside (GC) on male guinea pigs. "
05/01/1985 - "A chronic experimental allergic encephalomyelitis (EAE) was produced in Hartley guinea pigs with bovine white matter proteolipid protein (PLP), in which the levels of myelin basic protein (MBP) and galactocerebroside (GC) were less than 0.014% and 0.13%, respectively, by our method of purification. "
10/01/1988 - "Optic nerve and spinal cord tissue from untreated guinea pigs with chronic relapsing experimental autoimmune encephalomyelitis, guinea pigs with experimental autoimmune encephalomyelitis in which the disease was treated with injections of myelin basic protein (MBP) combined with galactocerebroside (GC), and normal guinea pigs, has been studied morphologically, immunocytochemically and morphometrically. "
08/01/2005 - "Galactocerebroside, the major glycolipid of central nervous system myelin, is a known target for pathogenic demyelinating antibody responses in experimental allergic encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). "

04/01/1986 - "Anti-galactocerebroside antibody in rabbits with experimental allergic neuritis."
03/01/1986 - "Relation of clinical, serological, morphological, and electrophysiological findings in galactocerebroside-induced experimental allergic neuritis."
02/01/1986 - "Rabbits were immunized with galactocerebroside and a crush lesion was created in the tibial nerve before the onset of experimental allergic neuritis. "
03/01/1984 - "Experimental allergic neuritis was induced in male inbred Lewis rats immunized with myelin, P2 alone, P2 mixed with galactocerebroside and P2 mixed with glucocerebroside. "
01/01/1981 - "Experimental allergic neuritis induced by galactocerebroside."

01/01/2008 - "Hypothesized role of galactocerebroside and NKT cells in the etiology of multiple sclerosis."
12/01/1984 - "Serum complexes containing antibody reactive with galactocerebroside and ganglioside were present in 12 patients with multiple sclerosis and 3 with other neurological diseases. "
08/01/2005 - "Galactocerebroside, the major glycolipid of central nervous system myelin, is a known target for pathogenic demyelinating antibody responses in experimental allergic encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). "
01/01/1986 - "Light and electron microscopical studies of the immunoperoxidase staining of multiple sclerosis plaques using antisera to a feline-derived agent and to galactocerebroside."
08/01/2005 - "Antibody responses against galactocerebroside are potential stage-specific biomarkers in multiple sclerosis."