1,2-linoleoylphosphatidylcholine

used for premature induction of labor in rabbits; RN given refers to (all Z)-isomer

Also Known As:

1,2-dilinoleoyl-3-glycerophosphocholine; 1,2-linoleoyl-sn-glycero-3-phosphocholine; 1,2-linoleoylphosphatidylcholine, (R-(all Z))-isomer; 1,2-linoleoylphosphatidylcholine, 14C-labeled cpd, (R-(all Z))-isomer; DLPC lipid; dilinoleoyl phosphatidylcholine; dilinoleoyllecithin; dilinoleoylphosphatidylcholine; (all-Z)-4-hydroxy- N,N,N-trimethyl-10-oxo-7-((1-oxo-9,12-octadecadienyl)oxy)-3,5,9-trioxa-4-phosphaheptacosa-18,21-dien-1-aminium, hydroxide, inner salt, 4-oxide

Networked: 11 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Glycerophospholipids: 689
        Phosphatidylcholines: 2371
        1,2-linoleoylphosphatidylcholine: 11

Experts

1.	Benghuzzi, Hamed A: 1 article (01/2014)
2.	Kennedy, Kim: 1 article (01/2014)
3.	Tucci, Michelle A: 1 article (01/2014)
4.	Cao, Qi: 1 article (09/2007)
5.	Decarli, Leonore M: 1 article (09/2007)
6.	Leo, Maria A: 1 article (09/2007)
7.	Lieber, Charles S: 1 article (09/2007)
8.	Mak, Ki M: 1 article (09/2007)
9.	Ponomarenko, Anatoly: 1 article (09/2007)
10.	Ren, Chaoling: 1 article (09/2007)

Related Diseases

1.	Fibrosis (Cirrhosis) 06/01/1999 - "PPC (and its active component dilinoleoylphosphatidylcholine) also oppose hepatic oxidative stress and fibrosis. " 04/01/1999 - "The prevention of cirrhosis in alcohol-fed baboons by the administration of a soybean extract-43% to 50% of which was dilinoleoyl-phosphatidylcholine (DLPC) and 24% of which was 1,palmitoyl 2,linoleoyl-phosphatidylcholine (PLPC)-was associated with a significant reduction in the number of stellate cells transformed to myofibroblast-like cells. " 01/01/1994 - "PC prevents alcohol-induced fibrosis and cirrhosis in nonhuman primates, and dilinoleoylphosphatidylcholine appears to be the active species, possibly by promoting collagen breakdown." 09/01/1993 - "Therapy may eventually improve with the use of supernutrients such as S-adenosyl-L-methionine, which replenishes glutathione, restores methylation, and attenuates liver injury, as well as dilinoleoylphosphatidylcholine, which prevents cirrhosis." 05/01/1993 - "On the other hand, phosphatidylcholine, purified from polyunsaturated lecithin, was discovered to oppose the ethanol-induced fibrosis by decreasing the activation of lipocytes to transitional cells, and possibly also by stimulating collagenase activity, an effect for which dilinoleoylphosphatidylcholine, its major phospholipid species, was found to be responsible."
2.	Neuroblastoma 01/01/2014 - "Comparison of potential preventive therapeutic agents green tea, thymoquinone, and dilinoleoylphosphatidylcholine on human neuroblastoma cells." 01/01/2014 - "The objective of this study was to determine if pretreatment of human SH-SY5Y neuroblastoma cells, a model for AD, with antioxidants thymoquinone (TQ), epigallocatechin-3-gallate (EGCG), or dilinoleoylphosphatidylcholine (DLPC) 30 minutes prior to a challenge with tumor necrosis factor a (TNFa), an inflammatory mediator, can prevent oxidation of amyloid beta (Aß). "
3.	Atherosclerosis 09/01/2000 - "Thus, dilinoleoyl-phosphatidylcholine (the main component of PPC) protects against LDL oxidation, a possible mechanism for its reported anti-atherosclerosis effects."
4.	Experimental Liver Neoplasms 11/01/1999 - "To determine the responsible phosphatidylcholine species, a Morris hepatoma cell line (RH 7777) was incubated with 100 mumol/L arachidonate supplemented with 20 mumol/L dilinoleoylphosphatidylcholine or 20 mumol/L palmitoyllinoleoylphosphatidylcholine which comprise 42% and 24% of polyenylphosphatidylcholine, respectively or with equivalent amounts of polyenylphosphatidylcholine. "
5.	Liver Cirrhosis (Hepatic Cirrhosis) 05/01/2007 - "We incorporated the bioactive lipid dilinoleoylphosphatidylcholine (DLPC) into the membrane of liposomes, and then we evaluated its effect on hepatic stellate cell activation and liver fibrosis. "

Related Drugs and Biologics

1.	1- palmitoyl- 2- linoleoylphosphatidylcholine
2.	Amyloid beta-Peptides
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Antioxidants
5.	epigallocatechin gallate (epigallocatechin-3-gallate)
6.	thymoquinone
7.	S-Adenosylmethionine (Ademetionine)
8.	Phosphatidylcholines (Phosphatidylcholine)
9.	Liposomes (Liposome)
10.	Lipids

Related Therapies and Procedures

1.	Therapeutics