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aceglutamide aluminum (KW 110)
structure
Also Known As:
KW 110
; KW-110; N-acetyl-L-glutamine aluminum complex; pentakis(N(2)-acetyl-L-glutaminato)tetrahydroxytrialuminum
Networked:
6
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Neutral Amino Acids: 200
Glutamine: 7693
aceglutamide aluminum: 6
Basic Amino Acids: 178
Glutamine: 7693
aceglutamide aluminum: 6
Diamino Amino Acids: 101
Glutamine: 7693
aceglutamide aluminum: 6
Organic Chemicals: 133
Organometallic Compounds: 64
aceglutamide aluminum: 6
Related Diseases
1.
Stomach Ulcer (Gastric Ulcer)
04/01/1982 - "
Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats.
"
06/01/1974 - "
Effects of an antiulcer agent N-acetyl-L-glutamine aluminum complex (KW-110) on the duodenal and gastric ulcer models in the rat.
"
06/01/1982 - "
Oral administration of PANa inhibited the formation of esophageal ulcer by pylorus ligation more markedly than aceglutamide aluminum, whereas sodium alginate had no effect in a high dose of 500 mg/kg. In preventing gastric ulcer which occurred simultaneously with the esophageal ulcer after the pylorus ligation, aceglutamide aluminum was most potent, and PANa was as potent as sodium alginate.
"
01/01/1975 - "
Comparative clinical trials were conducted by the double-blind technique in a series of 302 cases of gastric ulcer at fifteen medical institutions in order to investigate the clinical course of peptic ulceration and the effect of pharmacotherapy on it, using N-acetyl-L-glutamine aluminum complex (KW) as test drug and basic aluminum sucrose sulfate (UL) as reference drug as well as an inactive placebo of lactose (PL) with the results as follows: In 12 weeks of treatment with inactive placebo, a higher cure rates were noted in inpatients than in outpatients, and in patients with ulceration in the corpus ventriculi than in those with ulceration at the angulus.
"
2.
Disease Progression
01/01/1975 - "
Comparative clinical trials were conducted by the double-blind technique in a series of 302 cases of gastric ulcer at fifteen medical institutions in order to investigate the clinical course of peptic ulceration and the effect of pharmacotherapy on it, using N-acetyl-L-glutamine aluminum complex (KW) as test drug and basic aluminum sucrose sulfate (UL) as reference drug as well as an inactive placebo of lactose (PL) with the results as follows: In 12 weeks of treatment with inactive placebo, a higher cure rates were noted in inpatients than in outpatients, and in patients with ulceration in the corpus ventriculi than in those with ulceration at the angulus.
"
3.
Ulcer
04/01/1982 - "
When aceglutamide aluminum (1,000 mg/kg x 2/day) was orally administered for 4 consecutive days beginning the day of the operation, this drug inhibited the ulcer index and the perforations in ulcerated regions by 18 and 66%, respectively.
"
04/01/1982 - "
Following daily oral administration for 14 consecutive days, aceglutamide aluminum (1,000 mg/kg x 2/day) brought about more potent effects than those following the 4 days administrations, and this drug showed a 37% inhibition of the ulcer index and a complete inhibition of the perforations.
"
04/01/1982 - "
From the above results, aceglutamide aluminum may accelerate ulcer repair by potentiating defensive factors through the increases of components forming the mucus and granuloma in ulcerated tissues.
"
04/01/1982 - "
Increasing action of aceglutamide aluminum on defensive factors in acetic acid ulcers of rats (author's transl)].
"
06/01/1982 - "
Oral administration of PANa showed a more protective effect than aceglutamide aluminum on the esophageal ulceration induced by the simultaneous ligations of the pylorus and limiting ridge, whereas sodium alginate in a high dose of 500 mg/kg had little effect on the ulcer formation.
"
4.
Peptic Ulcer (Peptic Ulcers)
08/01/1991 - "
[Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer].
"
5.
Granuloma
04/01/1982 - "
From the above results, aceglutamide aluminum may accelerate ulcer repair by potentiating defensive factors through the increases of components forming the mucus and granuloma in ulcerated tissues.
"
Related Drugs and Biologics
1.
Sucralfate (Carafate)
2.
Lactose
3.
Acetic Acid (Vinegar)
4.
N-Acetylneuraminic Acid (Sialic Acid)
5.
Uronic Acids
6.
Hydroxyproline (4 Hydroxyproline)
7.
Hexosamines
8.
Glutamine (L-Glutamine)
9.
Alginates
10.
6-acetylaminocaproic acid (acexamic acid)
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)
2.
Oral Administration
3.
Ligation
4.
Injections