4-(2-aminoethyl)benzenesulfonylfluoride (AEBSF)

Also Known As:

AEBSF; 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride; 4-(2-aminoethyl)benzenesulfonyl fluoride; 4-2(aminoethyl)-benzensulfonyl fluoride; 4-beta-aminoethylbenzolsulfofluoride; AEBSF cpd; Pefabloc; Benzenesulfonyl fluoride, 4-(2-aminoethyl)-

Networked: 26 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - 4-(2-aminoethyl)benzenesulfonylfluoride: 26

Experts

1.	Beek, J: 2 articles (11/2015 - 03/2015)
2.	Maes, D: 2 articles (11/2015 - 03/2015)
3.	Nauwynck, H: 2 articles (11/2015 - 03/2015)
4.	Van Soom, A: 2 articles (11/2015 - 03/2015)
5.	Arora, Naveen: 2 articles (04/2015 - 01/2012)
6.	Saw, Sanjay: 2 articles (04/2015 - 01/2012)
7.	Babici, Denis: 1 article (01/2020)
8.	Oydanich, Marko: 1 article (01/2020)
9.	Vatner, Dorothy E: 1 article (01/2020)
10.	Vatner, Stephen F: 1 article (01/2020)

Related Diseases

1.	Hypersensitivity (Allergy) 01/01/2012 - "In the present study, 4-(2-Aminoethyl) benzenesulfonyl fluoride (AEBSF) a serine protease inhibitor was evaluated for prophylactic and therapeutic treatment in mouse model of airway allergy. "
2.	Infections 01/01/2017 - "To gain insight into the mechanism of this inhibition, AEBSF treatment was applied during different phases of an infection cycle (pre-, peri- and post-inoculation treatment). " 01/20/2011 - "Pretreatment of C57Bl/6J mice with either AEBSF or a cocktail of AEBSF and pAB prior to infection with the H1N1 virus significantly reduced weight loss and led to a faster recovery of treated versus untreated mice while pAB alone exerted a very poor effect. " 01/20/2011 - "Furthermore, pretreatment of C57BL/6J mice with AEBSF prior to infection resulted in a significant reduction in the levels of both the H1N1 and H7N7 nucleoproteins in mice lungs and also a significant reduction in the levels of the HA transcript in the lungs of the H1N1--but not the H7N7-infected mice. " 10/02/2019 - "These results indicate that AEBSF reduces DENV infection via both viral and host protease activities." 10/02/2019 - "Moreover, AEBSF significantly inhibited HMGCR activity and intracellular cholesterol synthesis after DENV infection. "
3.	Sexually Transmitted Diseases (Sexually Transmitted Disease) 03/01/2015 - "AEBSF and STI can be used in the future IVF studies without compromising sperm quality." 11/01/2015 - "4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride but not STI reduced sperm binding to the ZP. " 11/01/2015 - "Total fertilization rates were respectively 65% and 53% (AEBSF) and 36% and 17% (STI). " 11/01/2015 - "4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride and STI significantly reduced total fertilization and polyspermy rate in cumulus-intact and cumulus-free oocytes (P < 0.05). " 11/01/2015 - "Only 40.4% (AEBSF) and 11.4% (STI) of spermatozoa completed a calcium-induced acrosome reaction compared to 86.7% of spermatozoa in the control group. "
4.	Allergic Rhinitis 11/01/2014 - "In the present study, the serine protease inhibitor 4-(2-aminoethyl) benzene sulfonyl fluoride hydrochloride (AEBSF) was evaluated for its prophylactic and therapeutic applications in a mouse model of allergic rhinitis (AR). "
5.	Melanoma (Melanoma, Malignant) 10/01/2003 - "More importantly, while zVAD-fmk could not rescue melanoma cells from etoposide-induced death, the combination with AEBSF resulted in substantial protection. " 08/19/2022 - "The addition of potent MMP inhibitors (batimastat, marimastat, ONO4817) and other protease inhibitors (such as aprotinin, Pefabloc SC and bestatin) to the brain endothelial cells, in the presence of various melanoma lines, showed no reduction in the melanoma mediated barrier disruption. " 03/20/1997 - "We show here that a cDNA encoding N-Oct 3 directs synthesis of both the N-Oct 3 and N-Oct 5 proteins and that the N-Oct 5 protein in neural and melanoma-cell extracts is also related to N-Oct 3. N-Oct 5, however, is apparently not expressed in vivo: It is not detected if cells are rapidly lysed in SDS or if extracts are prepared with a cocktail of protease inhibitors that includes the serine-protease inhibitor 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF). "

Related Drugs and Biologics

1.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
2.	Fluorides
3.	Nucleoproteins
4.	Benzene (Benzole)
5.	sulfuryl fluoride (sulfonyl fluoride)
6.	Trypsin Inhibitors
7.	Protease Inhibitors (Protease Inhibitor)
8.	Aprotinin (Trasylol)
9.	4-(2-aminoethyl)benzenesulfonylfluoride (AEBSF)
10.	Serine Proteases (Serine Protease)

Related Therapies and Procedures

1.	Therapeutics