2,6-diphenylhexamethylcyclotetrasiloxane

an organosilicon anti-androgenic compound with estrogenic activities; RN given refers to cpd without isomeric designation

Also Known As:

2,6-diphenylhexamethylcyclotetrasiloxane, (cis)-isomer; 2,6-diphenylhexamethylcyclotetrasiloxane, (trans)-isomer; Cisobitan; KABI 1774; KABI-1774; 2,2,4,6,6,8-hexamethyl-4,8-diphenylcyclotetrasiloxane

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/1983 - "Cisobitan in treatment of prostatic cancer. " 01/01/1983 - "Of 34 patients with poorly differentiated prostatic cancer 18 were given Cisobitan--and 16 were given Estracyt-treatment. " 01/01/1983 - "In a multicenter study a total of 140 patients with well and moderately well differentiated prostatic cancer were randomly allocated to treatment with Cisobitan or Estradurin/Etivex, 70 to each group. " 01/01/1978 - "It is therefore doubtful whether Cisobitan will be a reasonable alternative to estrogens in the treatment of patients with advanced prostatic cancer."
2.	Carcinoma (Carcinomatosis) 01/01/1978 - "Thirteen patients with stage III or IV carcinoma of the prostate were treated with 2,6-cis-Diphenylhexamethylcyclotetrasiloxane (Cisobitan, a new organosilicon compound. " 01/01/1978 - "Prostatic carcinoma treated with 2,6-cis-diphenylhexamethylcyclotetrasiloxane (Cisobitan)." 01/01/1978 - "Two drugs, 2,6-cis-diphenylhexamethylcyclotetrasiloxane (Cisobitan) and estramustine-17-phosphate (Estracyt) were given to patients with poorly differentiated metastatic carcinoma of the prostate. "
3.	Neoplasms (Cancer) 01/01/1983 - "Of the 34 patients with poorly differentiated cancer, twelve were alive at the 24 months' follow up, six in the Cisobitan group and six in the Estracyt group." 01/01/1983 - "Cancer was responsible for the deaths in seven of the Cisobitan patients compared to four of the estrogen treated patients. "
4.	Body Weight (Weight, Body) 12/01/1972 - " KABI 1774 (2,6-cis-diphenylhexamethylcyclo-tetrasiloxane) was administered daily in a dose of 2 mg/kg body weight to rabbits for 2, 5, 10, 15, 20, 25, and 30 days, and in doses of 10 mg/kg and 250 mg/kg body weights to dogs for 40 days. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Estramustine
3.	polyestradiol phosphate (Estradurin)