triptolide

also has antiangiogenic, anti-inflammatory, and neuroprotective activities; a phytogenic antineoplastic agent; a tri-epoxide phenanthrene from Chinese herb, Tripterygium wilfordii; structure

Also Known As:

Networked: 960 relevant articles (122 outcomes, 241 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dudeja, Vikas: 27 articles (01/2022 - 10/2007)
2.	Saluja, Ashok K: 27 articles (01/2022 - 10/2007)
3.	Banerjee, Sulagna: 23 articles (07/2019 - 10/2012)
4.	Jiang, Zhenzhou: 20 articles (11/2021 - 01/2008)
5.	Zhang, Luyong: 20 articles (11/2021 - 01/2008)
6.	Vickers, Selwyn M: 18 articles (07/2019 - 10/2007)
7.	Sangwan, Veena: 17 articles (07/2019 - 08/2010)
8.	Wang, Tao: 14 articles (03/2021 - 01/2008)
9.	Wang, Wei: 13 articles (02/2022 - 01/2007)
10.	Huang, Xin: 13 articles (03/2021 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Triptolide (TP) is highly effective against multiple cancers including HCC. " 06/01/2015 - "Triptolide, a natural compound isolated from the Chinese herb Tripterygium wilfordii, is effective against multiple cancers. " 01/01/2022 - "Triptolide (TP) has demonstrated innumerous biological effects and pharmacological potential against different cancer types. " 04/20/2022 - "As a natural product with various biological activities, triptolide (TP) has been reported in anti-inflammatory, anti-tumor and anti-autoimmune studies. " 01/01/2021 - "Many studies have confirmed that triptolide (TPL), one of the principal components of Tripterygium wilfordii, possesses broad-spectrum anti-tumor activity. "
2.	Rheumatoid Arthritis 01/01/2022 - "Triptolide (TP), a major active component of the herb Tripterygium wilfordii Hook F (TwHF), has been shown to exert therapeutic potential against rheumatoid arthritis (RA). " 02/01/2021 - "Triptolide, a component of the Chinese herb Tripterygium wilfordii Hook F, has been proved to be effective in the treatment of rheumatoid arthritis (RA). " 04/02/2016 - "Triptolide (TP), an active component isolated from Tripterygiumwilfordii Hook F, has therapeutic potential against rheumatoid arthritis (RA). " 06/09/2023 - "In this study, triptolide (TPL), an effective ingredient in the treatment of rheumatoid arthritis (RA), was prepared in the form of a nanoparticle thermosensitive gel (TPL-NS-Gel). " 02/01/2019 - "This study aims to discuss the effect of triptolide (TPL) on rheumatoid arthritis (RA) and the mechanism related to osteoclast precursor (OCP) and osteoclast (OC). "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2017 - "Effect of the Natural Product Triptolide on Pancreatic Cancer: A Systematic Review of Preclinical Studies." 06/28/2014 - "Our study provides a mechanism by which triptolide sensitizes TRAIL resistant cells, which may become a novel therapeutic strategy against pancreatic cancer. " 11/22/2013 - "In this study, we evaluated the mechanism by which triptolide affects glycosylation of Sp1, which in turn affects downstream pathways controlling survival of pancreatic cancer cells. " 10/01/2010 - "Our study shows for the first time that induction of autophagy by triptolide has a pro-death role in pancreatic cancer cells. " 10/01/2010 - "However, the mechanism by which triptolide kills pancreatic cancer cells was not known, hence, this study aimed at elucidating it. "
4.	Autoimmune Diseases (Autoimmune Disease) 11/07/2021 - "This review aims to reveal the potential therapeutic prospect and limitations of triptolide in treating autoimmune diseases, thus providing guiding suggestions for further study and promoting its clinical translation." 04/01/2010 - "This study provides mechanistic insights into the immunomodulatory capacity of triptolide and has strong implications for its therapeutic applications in autoimmune diseases." 11/07/2021 - "In this review, the pharmacodynamic effects and pharmacological mechanisms of triptolide in autoimmune diseases are summarized. " 11/07/2021 - "Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity." 01/01/2021 - "Triptolide has shown a good immunosuppressive effect on autoimmune diseases. "
5.	Inflammation (Inflammations) 01/01/2022 - "Thus, our results highlight that triptolide alleviates whiter matter injury induced by chronic cerebral hypoperfusion through direct protection against oligodendrocyte apoptosis and indirect protection by inhibition of microglial inflammation. " 08/01/2023 - "In addition to the loss of germ cells, our results revealed increased macrophages and the inflammatory response in triptolide-treated mouse testes, suggesting a critical role of inflammation in triptolide-induced testicular injury. " 05/01/2023 - "Inflammation and oxidative stress are the two main ways triptolide exerts different roles, and the cross-talk between NF-κB and Nrf2 may be one of the mechanisms responsible for the dual role of triptolide and may represent the scientific connotation of You Gu Wu Yun. " 10/01/2021 - "Triptolide inhibition of p65 phosphorylation and acetylation could be an effective therapeutic approach in averting PM2.5-induced airway inflammation and bronchial hyperresponsiveness." 01/23/2020 - "Also, intragraft inflammation was markedly lower in triptolide-treated lungs because of inhibition of nuclear factor-κB signaling. "

Related Drugs and Biologics

1.	Diterpenes
2.	14-O-phosphonooxymethyltriptolide disodium salt
3.	Prodrugs
4.	Glucose (Dextrose)
5.	Cisplatin (Platino)
6.	triptolide
7.	Lipopolysaccharides
8.	celastrol
9.	NF-kappa B (NF-kB)
10.	Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Intra-Articular Injections
4.	Drug Therapy (Chemotherapy)
5.	Stents