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tempol

tempo is paramagnetic radical used in NMR as SPIN LABELS whereas TEMPO-H is not

Also Known As:

2,2,6,6-tetramethyl-4-piperidinol-N-oxyl; 4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine; 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl; 4-hydroxy-2,2,6,6-tetramethylpiperidinoxy radical; 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxy; HyTEMPO; N-Oxyl-2,2,6,6-tetramethylpiperidine; TMPN; nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-N-oxyl; nitroxyl-2 (2,2,6,6-tetramethyl 4-oxypiperidine)-1-oxyl; tanol

Networked: 424 relevant articles (65 outcomes, 69 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mitchell, James B: 21 articles (08/2015 - 01/2003)
2.	Augusto, Ohara: 9 articles (10/2013 - 01/2005)
3.	Krishna, Murali C: 9 articles (12/2012 - 01/2003)
4.	Fujita, Toshiro: 9 articles (09/2010 - 12/2002)
5.	Thiemermann, C: 9 articles (05/2004 - 02/2000)
6.	Cuzzocrea, S: 8 articles (01/2001 - 02/2000)
7.	Cook, John A: 7 articles (08/2015 - 01/2003)
8.	Sowers, Anastasia L: 7 articles (05/2015 - 01/2003)
9.	McDonald, M C: 7 articles (05/2004 - 02/2000)
10.	Nishiyama, Akira: 6 articles (01/2012 - 03/2004)

Related Diseases

1.	Hypertension (High Blood Pressure) 04/01/2005 - "Also, tempol is effective in reducing blood pressure in females only when given prior to the onset of hypertension." 03/01/2004 - "Tempol prevented and partially reversed Dex-induced hypertension, independent of improvement in systemic oxidative stress measured by F(2)-isoprostane concentrations." 09/01/2010 - "Tempol improved salt-induced hypertension and renal injury, even after its discontinuation. " 09/01/2007 - "Acute or chronic treatment with the O2(-) scavenger tempol in experimental models of hypertension (induced by chronic low-dose treatment with AngII and NO inhibitors) causes an improvement in renal haemodynamics and in excretory function, abolishes salt sensitivity and reduces blood pressure. " 05/01/2015 - "Tempol mitigates oxidative stress, blocks AP1-SP3 activation, and prevents D1R dysfunction and hypertension. "
2.	Inflammation 05/01/2010 - "Thus, tempol has been effective in preventing several of the adverse consequences of oxidative stress and inflammation that underlie radiation damage and many of the diseases associated with aging. " 01/15/2005 - "These studies may contribute to the understanding of the protective effects of tempol in animal models of inflammation." 07/01/2014 - "These results suggest that the reduction of mortality by tempol is due to amelioration of chronic inflammation and improved function of the immune system through antioxidant effects. " 01/01/2014 - "Notably, Tempol (20 mg/kg) partially increased the survival of mice with CM. Mechanistically, treated mice had lowered plasma levels of MCP-1, suggesting that Tempol downmodulates EC function and vascular inflammation. " 05/01/2013 - "Tempol treatment attenuated inflammation but did not reduce the extent of histological cerebral damage."
3.	Fibrosis (Cirrhosis) 08/15/2012 - "Despite preserved GFR, renal perfusion was not improved by tempol, and MV density was further reduced compared with untreated RAS, associated with increased renal apoptosis and fibrosis. " 09/01/2015 - "Trichrome staining showed increased fibrosis in Dct-null atria, and treating Dct-null mice with the ROS scavenger Tempol reduced atrial fibrosis. " 12/01/2013 - "Collectively, our data suggest a potential protective role of tempol against diabetes-associated cardiac fibrosis in rats via reducing oxidative stress and extracellular matrix remodeling." 09/01/2005 - "Finally, supplementation of a SOD mimetic tempol did not prevent peroxidation and tubulointerstitial fibrosis in the acatalasemic remnant kidneys. " 05/20/2008 - "NOS recoupling by exogenous BH4 ameliorates preexisting advanced cardiac hypertrophy/fibrosis and is more effective than a less targeted antioxidant approach (Tempol). "
4.	Anoxia (Hypoxia) 02/01/2012 - "Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia." 09/01/2015 - "The aim of this study was to examine the effect of lymphocytes from intermittent hypoxia-exposed rats on the apoptotic signals in endothelial cells and the interventional role of tempol. " 09/01/2015 - "Lymphocytes from intermittent hypoxia-exposed rats increased the apoptotic signals in endothelial cells via oxidative and inflammatory injury in vitro, which could be attenuated by tempol." 08/01/2015 - "We found that tempol, a nitroxide, strongly induces the accumulation of hypoxia-inducible factor (HIF)-1α, particularly under conditions of hypoxia. " 01/01/2015 - "Bcl-xL knockdown and Tempol treatment inhibited cycling hypoxia-induced chemoresistance. "
5.	Ischemia 03/01/2007 - "In this study, we aimed to investigate whether tempol prevents harmful systemic effects of superior mesenteric ischemia-reperfusion on left colonic anastomosis in rats. " 07/01/2000 - "In this study, we compared the abilities of PNA, Tempol, and the combination of PNA + Tempol to prevent lung microvascular injury secondary to prolonged gut ischemia (I, 120 min) and reperfusion (R, 20 min) in the rat. " 06/01/2010 - "Tempol protects the gallbladder against ischemia/reperfusion." 04/01/2010 - "The cell-permeative antioxidant Tempol inhibited the stimulatory effect of ischemia-reperfusion. " 01/01/2009 - "We investigated whether Tempol, a water-soluble antioxidant, prevents the harmful effects of superior mesenteric ischemia/reperfusion on intestinal tissues in rats. "

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2.	Superoxides (Superoxide)
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4.	Creatinine
5.	NG-Nitroarginine Methyl Ester (L-NAME)
6.	Catalase
7.	Glutathione Reductase (Glutathione-Disulfide Reductase)
8.	Glutathione Peroxidase
9.	Enzymes
10.	Insulin (Novolin)

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5.	Ligation