tempol

tempol is paramagnetic radical used in NMR as SPIN LABELS whereas TEMPO-H is not

Also Known As:

2,2,6,6-tetramethyl-4-piperidinol-N-oxyl; 4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine; 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl; 4-hydroxy-2,2,6,6-tetramethylpiperidinoxy radical; 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxy; HyTEMPO; N-Oxyl-2,2,6,6-tetramethylpiperidine; TMPN; nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-N-oxyl; nitroxyl-2 (2,2,6,6-tetramethyl 4-oxypiperidine)-1-oxyl; tanol

Networked: 628 relevant articles (98 outcomes, 107 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mitchell, James B: 24 articles (01/2022 - 01/2003)
2.	Krishna, Murali C: 11 articles (01/2022 - 01/2003)
3.	Augusto, Ohara: 10 articles (09/2020 - 01/2005)
4.	Fujita, Toshiro: 10 articles (11/2018 - 12/2002)
5.	Thiemermann, C: 9 articles (05/2004 - 02/2000)
6.	Cook, John A: 8 articles (01/2022 - 01/2003)
7.	Sowers, Anastasia L: 8 articles (01/2022 - 01/2003)
8.	Cuzzocrea, S: 8 articles (01/2001 - 02/2000)
9.	Tanus-Santos, Jose E: 7 articles (10/2021 - 05/2009)
10.	Nagasaki, Yukio: 7 articles (01/2021 - 01/2011)

Related Diseases

1.	Inflammation (Inflammations) 09/30/2015 - "To evaluate the protective effects of TEMPOL on oxidative stress, inflammation, tissue injury, and renal hemodynamics and oxygenation in a clinically representative rat model of I/R using aortic cross-clamping. " 05/01/2010 - "Thus, tempol has been effective in preventing several of the adverse consequences of oxidative stress and inflammation that underlie radiation damage and many of the diseases associated with aging. " 01/15/2005 - "These studies may contribute to the understanding of the protective effects of tempol in animal models of inflammation." 05/30/2023 - "The therapeutic benefits of Tempol-Lips primarily are ascribed to the reduced local and systematic oxidative stress and inflammation. " 05/30/2023 - "The obtained Tempol-Lips can be efficiently internalized into inflammatory macrophages and attenuated inflammation via scavenging overproduced intracellular ROS. "
2.	Hypertension (High Blood Pressure) 04/01/2005 - "Also, tempol is effective in reducing blood pressure in females only when given prior to the onset of hypertension." 03/01/2004 - "Tempol prevented and partially reversed Dex-induced hypertension, independent of improvement in systemic oxidative stress measured by F(2)-isoprostane concentrations." 01/01/1999 - "The present study was designed to test whether prolonged administration of tempol ameliorates oxidative stress and hypertension in SHR. " 01/01/2020 - "Tempol or Vit-C did not reverse hypertension, and the high basal tone was decreased only with tempol. " 01/01/2019 - "Tempol also decreased hypertension-induced aortic oxidative stress and the enhanced MMP-2 activity. "
3.	Fibrosis (Cirrhosis) 08/15/2012 - "Despite preserved GFR, renal perfusion was not improved by tempol, and MV density was further reduced compared with untreated RAS, associated with increased renal apoptosis and fibrosis. " 11/05/2018 - "Finally, Tempol attenuated mesangial fibrosis in db/db mice. " 09/01/2015 - "Trichrome staining showed increased fibrosis in Dct-null atria, and treating Dct-null mice with the ROS scavenger Tempol reduced atrial fibrosis. " 12/01/2013 - "Collectively, our data suggest a potential protective role of tempol against diabetes-associated cardiac fibrosis in rats via reducing oxidative stress and extracellular matrix remodeling." 09/01/2005 - "Finally, supplementation of a SOD mimetic tempol did not prevent peroxidation and tubulointerstitial fibrosis in the acatalasemic remnant kidneys. "
4.	Hypoxia (Hypoxemia) 02/01/2012 - "Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia." 04/15/2017 - "Biochemical, molecular and behavioral studies suggest the role of tempol in preserving mitochondrial function and associated neurobehavioral outcomes after neonatal anoxia." 09/01/2015 - "The aim of this study was to examine the effect of lymphocytes from intermittent hypoxia-exposed rats on the apoptotic signals in endothelial cells and the interventional role of tempol. " 04/21/2017 - "Protective Effect of Tempol Against Hypoxia-Induced Oxidative Stress and Apoptosis in H9c2 Cells." 12/28/2015 - "Bcl-xL knockdown and Tempol treatment inhibited cycling hypoxia-induced chemoresistance. "
5.	Ischemia 07/01/2000 - "In this study, we compared the abilities of PNA, Tempol, and the combination of PNA + Tempol to prevent lung microvascular injury secondary to prolonged gut ischemia (I, 120 min) and reperfusion (R, 20 min) in the rat. " 01/01/2018 - "On day 12 of gestation ( GD12), 1 × 106 placental ischemia-stimulated TH17 cells were injected into normal pregnant (NP) rats (NP + RUPP TH17 rats), and a subset of rats were treated with tempol (30 mg·kg-1·day-1) from GD12 to GD19 (NP + RUPP TH17 + tempol rats). " 01/01/2017 - "Further, when previously treated with tempol, glycolytic muscle was largely protected against the deleterious effects of ischemia-reperfusion. " 06/01/2010 - "Tempol protects the gallbladder against ischemia/reperfusion." 01/01/2008 - "The mechanism of proarrhythmic tempol action during ischemia and reperfusion remains to be elucidated."

Related Drugs and Biologics

1.	Antioxidants
2.	Superoxide Dismutase
3.	nitroxyl
4.	Superoxides (Superoxide)
5.	Urea (Carbamide)
6.	NG-Nitroarginine Methyl Ester (L-NAME)
7.	Creatinine
8.	Enzymes
9.	Catalase
10.	Streptozocin (Streptozotocin)

Related Therapies and Procedures

1.	Resuscitation
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)
4.	Cardiopulmonary Resuscitation (CPR)
5.	Intravenous Injections