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auromomycin
C35H33NO12; macromomycin is the apoprotein of auromomycin which is the cytotoxic chromophore
Also Known As:
aur-chromophore; macromomycin chromophore
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
auromomycin: 6
Related Diseases
1.
Neoplasms (Cancer)
08/01/1984 - "
Experimental pharmacology of auromomycin in L1210 tumor cells in vitro and in vivo.
"
07/01/1979 - "
The mechanism of action of auromomycin, a new tumor-inhibitory antibiotic, was studied in a growing culture of mouse lymphoblastoma L5178Y cells and with isolated viral DNA.
"
04/01/1983 - "
In our laboratory, we have studied the mechanism of action of tumor-inhibitory antibiotics, including bleomycin, phleomycin, adriamycin, aclarubicin, neothramycin, macromomycin, auromomycin, chartreusin, pluramycin, neopluramycin, xanthomycin A, angustmycins A and C, blasticidin S and phenomycin.
"
2.
Carcinoma (Carcinomatosis)
06/01/1983 - "
The free chromophores isolated from the antitumor protein antibiotics, auromomycin (AUR) and macromomycin (MCR), were rapidly inactivated by incubation in serum-containing medium at 37 degrees C in the dark with respect to cytocidal activity to human lung carcinoma A549 cells.
"
06/01/1983 - "
With the use of three human lung cultured cell lines: normal diploid fibroblasts (WI38), their SV40-transformants (VA13) and carcinoma cells (A549), whose doubling times were similar, the cytotoxicity of the protein antitumor antibiotics, auromomycin (AUR) and macromomycin (MCR), was studied by colony formation method.
"
06/01/1983 - "
Differential cytotoxicity to human lung normal diploid, virus-transformed and carcinoma cells by the antitumor antibiotics, auromomycin and macromomycin, and their non-protein chromophores.
"
04/01/1979 - "
Antitumor activities of auromomycin were revealed against EHRLICH ascites carcinoma, ascites sarcoma 180, L1210 leukemia and LEWIS lung carcinoma.
"
06/01/1983 - "
Role of pronase-resistant peptide segments of the antitumor protein antibiotics, auromomycin and macromomycin, in stabilizing cytocidal activity of the chromophore moieties to carcinoma cells.
"
3.
Lewis Lung Carcinoma
04/01/1979 - "
Antitumor activities of auromomycin were revealed against EHRLICH ascites carcinoma, ascites sarcoma 180, L1210 leukemia and LEWIS lung carcinoma.
"
4.
Sarcoma 180
04/01/1979 - "
Antitumor activities of auromomycin were revealed against EHRLICH ascites carcinoma, ascites sarcoma 180, L1210 leukemia and LEWIS lung carcinoma.
"
5.
Leukemia L1210
04/01/1979 - "
Antitumor activities of auromomycin were revealed against EHRLICH ascites carcinoma, ascites sarcoma 180, L1210 leukemia and LEWIS lung carcinoma.
"
Related Drugs and Biologics
1.
Anti-Bacterial Agents (Antibiotics)
2.
Proteins (Proteins, Gene)
3.
Aclarubicin
4.
Pronase
5.
Phleomycins
6.
Peptides (Polypeptides)
7.
Doxorubicin (Adriamycin)
8.
Viral DNA
9.
Bleomycin (Blenoxane)
10.
phenomycin