hyperforin

a prenylated acylphloroglucinol derivative; antibiotic component of novoimanine; psychoactive agent in St. John's wort; Russian; structure;

Also Known As:

IDN5607; IDN5706; octahydrohyperforin; tetrahydrohyperforin; 4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-pentenyl) bicyclo(3.3.1)non-3-ene-2,9-dione

Networked: 100 relevant articles (10 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - hyperforin: 100
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phloroglucinol: 132
        hyperforin: 100

Experts

1.	Garbisa, Spiridione: 6 articles (01/2011 - 09/2004)
2.	Inestrosa, Nibaldo C: 5 articles (02/2016 - 03/2010)
3.	Schempp, Christoph M: 5 articles (02/2014 - 02/2002)
4.	Billard, C: 5 articles (01/2013 - 03/2006)
5.	Inestrosa, N C: 4 articles (01/2014 - 11/2006)
6.	Dell'Aica, Isabella: 4 articles (01/2008 - 09/2004)
7.	Chen, Wei-Ting: 3 articles (10/2020 - 01/2017)
8.	Hsu, Fei-Ting: 3 articles (10/2020 - 01/2018)
9.	Fedoročko, Peter: 3 articles (06/2019 - 12/2012)
10.	Zhang, Yujing: 3 articles (01/2019 - 01/2016)

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 03/01/2003 - "In a half-side comparison study we assessed the efficacy of a cream containing Hypericum extract standardized to 1.5% hyperforin (verum) in comparison to the corresponding vehicle (placebo) for the treatment of subacute atopic dermatitis. " 01/01/2003 - "In the present half-side comparison study we assessed the efficacy of a cream containing Hypericum: extract standardised to 1.5% hyperforin (verum) in comparison to the corresponding vehicle (placebo) for the treatment of subacute Atopic Dermatitis. " 01/01/2017 - "We also applied hyperforin/HP-β-CD on an ex vivo skin model of atopic dermatitis and found that hyperforin/HP-β-CD treatment for 24 h improved the stretch-induced Ca2+ responses and oscillations which failed in atopic skin."
2.	Inflammation (Inflammations) 12/01/2023 - "Silencing of BCL6 reversed the effects of hyperforin on IL-13-induced inflammation and barrier damage. " 01/01/2023 - "Hyperforin, an active constituent from Hypericum perforatum, has been reported to inhibit inflammation. " 05/01/2009 - "These results highlight the potential for Hyperforin as an anti-inflammatory angioprevention agent, acting as a strong inhibitor of inflammation- or tumour-triggered angiogenesis, and provide new therapeutic approaches to halting pathology-associated angiogenesis." 01/01/2021 - "Recent studies have reported that hyperforin reduced inflammation in stroke and suppressed proliferation and differentiation in keratinocytes. " 12/01/2023 - "In summary, the present results revealed that hyperforin suppressed IL-13-induced nasal epithelial cell inflammation and barrier damage by targeting BCL6/p38 MAPK/CCL11, which may provide promising therapeutic targets for AR."
3.	Ischemic Stroke 02/01/2013 - "However, the protective effects of hyperforin on ischemic stroke in vivo remain controversial and its neuroprotective mechanisms are still unclear. " 01/01/2019 - "Hyperforin has been shown to be capable of promoting angiogenesis and functional recovery after ischemic stroke in our previous study. " 01/01/2018 - "Hyperforin, a pharmacologically active component of the medicinal plant Hypericum perforatum (St. John's wort), has been shown to be neuroprotective against acute ischemic stroke. " 01/01/2016 - "Hyperforin, the main active ingredient of the medicinal plant Hypericum perforatum, has been shown to be neuroprotective against acute ischemic stroke. " 01/01/2016 - "Thus, our results suggest that, in addition to the acute neuroprotection when delivered immediately after ischemic stroke, hyperforin could also promote functional recovery when delivered in the later phases of stroke recovery. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2021 - "Our study provided a novel therapeutic tragedy for psoriasis by which hyperforin attenuates psoriasis-related inflammatory responses." 01/01/2021 - "Hyperforin also suppressed the typical psoriasis-like inflammatory responses and the infiltration of IL-17A+ cells in dermal γδ T cells of IMQ treated Tcrd-/- mice transferred with γδ T cells. " 01/01/2021 - "To investigate the underlying inflammatory mechanisms and response of hyperforin in psoriasis, we use imiquimod (IMQ)-induced mice model, in vitro cultured murine splenic γδ T cells, and HaCaT cells in this study. " 01/01/2021 - "Hyperforin Ameliorates Imiquimod-Induced Psoriasis-Like Murine Skin Inflammation by Modulating IL-17A-Producing γδ T Cells." 01/01/2021 - "In conclusion, hyperforin alleviates IMQ-induced inflammation in psoriasis through suppressing the immune responses exerted by IL-17 A-producing γδ T cells and related cytokines by modulating MAPK/STAT3 pathways. "
5.	Depressive Disorder (Melancholia) 12/01/1998 - "Clinical significance of hyperforin for the efficacy of Hypericum extracts on depressive disorders of different severities." 07/01/2001 - "Hyperforin, an acylphloroglucinol derivative, is a major constituent of St. John's wort extract (Hypericum perforatum L.), which is used in treating depressive disorders. " 10/01/2020 - "Hyperforin, an herb compound derived from St. John's wort was used to treat depressive disorder by inhibiting neuronal reuptake of several neurotransmitters. " 11/01/2010 - "On the other hand, ethanolic extracts containing hypericin and hyperforin affect the CNS and are indicated for the treatment of episodes of mild depressive disorders. " 07/01/2001 - "Since hyperforin-free extract, like conditioned fear, reduces the extracellular concentration of serotonin, hyperforin may be more beneficial than Hypericum extract in the treatment of depressive disorders."

Related Drugs and Biologics

1.	Imiquimod (Aldara)
2.	TRPC6 Cation Channel
3.	Interleukin-17 (Interleukin 17)
4.	Scopolamine (Hyoscine)
5.	hypericin
6.	Salts
7.	Rifampin (Rifampicin)
8.	Quercetin
9.	Cytochrome P-450 CYP2C9
10.	Phenobarbital (Luminal)

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)
3.	Injections
4.	Drug Therapy (Chemotherapy)
5.	Treatment Delay