alexidine

11/01/1977 - "The results indicated that alexidine.2HCL was safe and was statistically more effective in producing a clinically significant reduction in gingivitis than was the placebo."
11/01/1975 - "The alexidine mouthwash was statistically and clinically effective in decreasing plaque scores and plaque weight, and statistically but not clinically effective in decreasing gingivitis scores. "
03/01/1977 - "The primary purpose of this study was to determine the safety and effectiveness of alexidine in the control of plaque and gingivitis in humans. "
03/01/1978 - "A clinical study was conducted on the effects of an alexidine or placebo oral rinse on plaque and gingivitis. "
03/01/1978 - "The effect of an alexidine mouthwash on plaque and gingivitis."

01/01/2009 - "Alexidine was effective in killing the trophozoites at a concentration of 10 microg/mL. However, a higher concentration of Alexidine (100 microg/mL) is required to kill Acanthamoeba cysts and the cytotoxic activities of Alexidine are comparable with chlorhexidine. "
09/01/2019 - "With the diamidines, the presence of BAC in the propamidine drops was responsible for the activity against Acanthamoeba spp. Hexamidine drops without BAC showed good activity against trophozoites, and the biguanides polyhexamethylene biguanide, chlorhexidine, alexidine, and octenidine all showed excellent activity against trophozoites and cysts of both species. "

09/01/2006 - "The objective of this current study was to evaluate alexidine dihydrochloride as a novel compound lead for head and neck cancers. "

03/01/1979 - "Inhibitory effects of an alexidine mouthrinse on dental plaque formation."
04/01/1977 - "The effect of an alexidine mouthwash on dental plaque and gingivitis."
03/01/1977 - "Effects of an alexidine mouthwash on dental plaque and gingivitis in humans over a six-month period."
01/01/1988 - "Only the groups treated with alexidine chloride alone or in combination with sodium fluoride exhibited significantly less dental plaque (greater than or equal to 64%) than the rats in the placebo-treated groups."

09/01/2006 - "FaDu cell clonogenic survival was reduced to < 5% with 1 micromol/L alexidine dihydrochloride, and, correspondingly, this compound decreased the in vivo tumor-forming potential of FaDu cells. "
01/01/2020 - "In conclusion, considering its anti-cancer properties and bioavailability, Alexidine dihydrochloride can be considered as a potential candidate against pancreatic adenocarcinomas."
05/20/2022 - "Except for alexidine, these drugs inhibited the clonogenic ability and caspase activation in all cancer lines tested. "