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aeroplysinin

antibacterial cpd from sponge, Verongia aerophoba; structure

Also Known As:

3,5-dibromo-1,5-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonitrile

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexenes: 4
        aeroplysinin: 4
- Nitriles: 227
  - Acetonitriles: 2
    - aeroplysinin: 4

Experts

1.	García-Vilas, Javier A: 1 article (12/2015)
2.	Martínez-Poveda, Beatriz: 1 article (12/2015)
3.	Medina, Miguel Ángel: 1 article (12/2015)
4.	Quesada, Ana R: 1 article (12/2015)

Related Diseases

1.	Neoplasms (Cancer) 12/22/2015 - "In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. " 09/26/2022 - "(+)-Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that exhibits pleiotropic bioactive effects, impairing cell growth in cancer cells, inhibiting angiogenesis in vitro and in vivo and modulating the redox status of different cell types, among other reported activities. " 01/01/1990 - "5. From these data we conclude that (+)-aeroplysinin-1 represents a compound which displays a strong anti-tumor effect on EGF-dependent tumor cell lines."
2.	Lymphoma (Lymphomas) 07/01/1989 - "Furthermore, aeroplysinin caused a preferential inhibition of [3H]thymidine (dThd) incorporation rates in L5178y mouse lymphoma cells if compared with murine spleen lymphocytes in vitro. "
3.	Breast Neoplasms (Breast Cancer) 01/01/1990 - "2. (+)-Aeroplysinin-1 blocked the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibited the ligand-induced endocytosis of the EGF receptor in vitro. " 01/01/1990 - "Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1." 01/01/1990 - "1. (+)-Aeroplysinin-1, a naturally occurring tyrosine metabolite from the marine sponge Verongia aerophoba, was found to inhibit the phosphorylation of lipocortin-like proteins by a highly purified preparation of the epidermal growth factor (EGF) receptor-tyrosine protein kinase complex from MCF-7 breast carcinoma cells. "

Related Drugs and Biologics

1.	ErbB Receptors (EGF Receptor)
2.	Annexins
3.	Tyrosine (L-Tyrosine)
4.	Thymidine
5.	Proteins (Proteins, Gene)
6.	Protein-Tyrosine Kinases (Tyrosine Kinase)
7.	Phosphotransferases (Kinase)
8.	Ligands
9.	Epidermal Growth Factor (EGF)