improsan

synonyms NSC-102627, alkylating agent 864 & yoshi 864 refer to HCl; RN given refers to parent cpd; structure

Also Known As:

3,3'-iminodi-1- propanol dimethanesulfonate; 864 T; NSC-102627; NSC-140117; alkylating agent 864; bis(3-mesyloxypropyl)amine; dimesyloxydipropylamine tosylate; improsan hydrochloride; improsan tosylate; yoshi 864; 3,3'-iminobis-1-propanol dimethanesulfonate

Networked: 7 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Alkanesulfonic Acids
        Alkanesulfonates: 9
        Mesylates: 334
        improsan: 7
- Sulfur Compounds: 278
  - Sulfur Acids
    - Sulfonic Acids: 1605
      - Alkanesulfonic Acids
        Alkanesulfonates: 9
        Mesylates: 334
        improsan: 7

Related Diseases

1.	Neoplasms (Cancer) 03/01/1978 - "Yoshi 864 (1-propanol, 3,3'-iminodi-, dimethanesulfonate [ester], hydrochloride): a phase II study in solid tumors."
2.	Bronchogenic Carcinoma 03/01/1975 - "A new drug, NSC-140117, was used in the management of 15 patients who had late bronchogenic carcinoma and were unable to receive surgical or radiotherapeutic treatment. " 03/01/1975 - "Chemotherapeutic management of bronchogenic carcinoma: trials with NSC-140117, a new methanesulfonic acid ester of aminoglycol."
3.	Adenocarcinoma 09/01/1982 - "Yoshi 864 plus medroxyprogesterone acetate in adenocarcinoma of the kidney: A Southwest Oncology Group Study."
4.	Ovarian Epithelial Carcinoma 09/01/1982 - "Phase II clinical study of Yoshi 864 in epithelial ovarian carcinoma: A Gynecologic Oncology Group Study."
5.	Lymphoma (Lymphomas) 03/01/1978 - "Because of its lack of toxicity, Yoshi 864 should be further evaluated in chronic myelocytic leukemia, lymphomas, and carcinomas of the ovary and bladder where significant responses were seen. " 11/01/1976 - "Survival and cycle-progression delay of cultured human lymphoma cells treated with 1-propanol, 3,3'-iminodi-, dimethanesulfonate (ester), hydrochloride (Yoshi 864)." 04/01/1973 - "Clinical experience with two new methanesulfonic acid esters of aminoglycols, NSC-140115 and NSC-140117, in the treatment of malignant lymphoma." 11/01/1976 - "Asynchronous human lymphoma cells treated for 1 hour with increasing concentrations of 1-propanol, 3,3'-iminodi-, dimethanesulfonate (ester), hydrochloride (Yoshi 864) revealed a shouldered survival curve typical of the effects of alkylating agents and of ionizing radiation on this cell line. "

Related Drugs and Biologics

1.	Esters
2.	1-Propanol (Propanol)
3.	methanesulfonic acid (methanesulfonate)
4.	Medroxyprogesterone Acetate (Depo-Provera)
5.	Alkylating Agents