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N-hydroxy-2-aminofluorene
structure
Also Known As:
N-2-hydroxyaminofluorene
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Fluorenes: 7
N-hydroxy-2-aminofluorene: 4
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Fluorenes: 7
N-hydroxy-2-aminofluorene: 4
Related Diseases
1.
Neoplasms (Cancer)
07/01/1987 - "
Production of urothelial tumors in the heterotopic bladder of rats by instillation of N-glucuronosyl or N-acetyl derivatives of N-hydroxy-2-aminofluorene.
"
03/01/1987 - "
In the present study hepatic DNA adduct formation and tumor initiation by N-hydroxy-2-aminofluorene (N-hydroxy-AF) were examined in these mice.
"
02/01/1991 - "
The N-glucuronide of N-hydroxy-2-aminofluorene, a positive control, produced urothelial tumors.
"
07/01/1988 - "
Deacetylation of N-hydroxy-2-acetylaminofluorene (N-hydroxy-AAF) to N-hydroxy-2-aminofluorene (N-hydroxy-AF) has been proposed as one of the critical metabolic steps in the formation of hepatic DNA adducts and the initiation of liver tumors in 12-day-old male B6C3F1 mice.
"
Related Drugs and Biologics
1.
DNA Adducts
2.
Glucuronides