helenalin

01/01/2016 - "In this study, we demonstrated that the NC-helenalin complex is more effective than free helenalin in inhibiting the growth of breast cancer cells."
01/01/2023 - "These preliminary results demonstrated the cytotoxic potential of helenalin through inhibition of hTERT against T47D breast cancer cells."
01/01/2023 - "We used the MTT assay to evaluate the cytotoxic effect of different concentrations of helenalin on the T47D breast cancer cell line at 24, 48, and 72 hours. "
01/01/2016 - "The purpose of this study was to examine whether nano encapsulating helenalin improves the anti-cancer effect of free helenalin in the T47D breast cancer cell line. "
01/01/2023 - "In this study, we investigated the inhibitory effect of helenalin extract on telomerase gene expression in the T47D breast cancer cell line. "

03/15/2022 - "This study aimed to investigate the protective mechanisms of helenalin on hepatic fibrosis. "
03/15/2022 - "Comprehensive analysis of transcriptomics and metabolomics to illustrate the underlying mechanism of helenalin against hepatic fibrosis."
03/15/2022 - "In conclusion, helenalin ameliorates hepatic fibrosis by regulating the PI3K/Akt and NF-κB signaling pathways and the glycerophospholipid metabolism pathway."
06/01/2014 - "In conclusion, helenalin had a significant protective effect on chronic ethanol-induced hepatic fibrosis and may be a major bioactive ingredient of C. "
06/01/2014 - "Helenalin attenuates alcohol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and suppressing HSC activation."

03/01/1985 - "A series of analogues related to helenalin demonstrated moderate capability for inhibiting the growth of murine P-388 lymphocytic leukemia cells in vivo and in vitro. "
03/10/1983 - "The mode of action of helenalin and bis(helenalinyl) malonate as protein synthesis inhibitors of P-388 lymphocytic leukemia cells was investigated. "
02/01/1988 - "Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo."
12/01/1989 - "Combination of helenalin 8 mg/kg/day i.p.) with L-cysteine (100 mg/kg/day), beta-mercaptoethanolamine (20 mg/kg/day), 18-beta-glycyrrhetinic acid (15 mg/kg/day), or 4,4'-diaminodiphenylsulfone (10 mg/kg/day) afforded improvement in survival of mice bearing P-388 lymphocytic leukemia. "
01/01/1988 - "Helenalin and bis (helenalinyl) malonate, sesquiterpene lactones, were shown to be cytotoxic against the growth of P-388 lymphocytic leukemia cells in culture. "

01/01/2020 - "The promising anti-cancer potential of helenalin in various preclinical studies may open new avenues for therapeutic interventions in different tumors. "
01/01/2020 - "The objective of the present study is to overview the recent patents of Arnica and its principal constituent helenalin, including new methods of isolation, and their use in the prevention of cancer and other ailments. "
06/14/2021 - "BACKGROUND Helenalin is a pseudoguaianolide natural product with anti-cancer activities. "
01/01/2020 - "Helenalin has shown its anti-cancer potential to treat multiple types of tumors, both in vitro and in vivo. "
01/01/2020 - "Current prose and patents emphasizing the anti-cancer potential of helenalin and Arnica, incorporated as anti-inflammary agents in anti-cancer preparations, have been identified and reviewed with particular emphasis on their scientific impact and novelty. "

09/01/2019 - "In conclusion, the present study reveals that helenalin sesquiterpene lactone exhibits significant antitumor activity in doxorubicin-resistant acute myeloid leukemia HL60 cells by targeting some key pathways and as such this molecule could prove to be a potential drug candidate for future investigations."
09/01/2019 - "The main purpose of the current study was to investigate the antitumor effects of helenalin - a plant derived sesquiterpene lactone, against doxorubicin-resistant acute myeloid leukemia HL60 cells, along with evaluating its effects on apoptosis induction, mitochondrial membrane potential (MMP), cell migration and inhibition and PI3K/AKT/M-TOR signalling pathway. "