fenamic acid

has chloride and potassium channel-blocking activity; RN given refers to parent cpd

Also Known As:

4-(phenylamino)benzoic acid; N-phenylanthranilic acid; diphenylamine carboxylate; diphenylamine-2-carboxylate; diphenylamine-2-carboxylic acid; fenamic acid, Ca salt (2:1); fenamic acid, monosodium salt

Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Aminobenzoates: 1
        ortho-Aminobenzoates: 8
        fenamic acid: 16
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Aminobenzoates: 1
        ortho-Aminobenzoates: 8
        fenamic acid: 16

Experts

1.	Baek, Seung Joon: 1 article (06/2016)
2.	Ha, Taekyu: 1 article (06/2016)
3.	Lee, Seong-Ho: 1 article (06/2016)
4.	Lou, Zhiyuan: 1 article (06/2016)
5.	Hanafusa, Hiroyuki: 1 article (01/2013)
6.	Kato, Ikuo: 1 article (01/2013)
7.	Kondo, Chiaki: 1 article (01/2013)
8.	Maruyama, Toshiyuki: 1 article (01/2013)
9.	Minowa, Yohsuke: 1 article (01/2013)
10.	Morikawa, Yuji: 1 article (01/2013)

Related Diseases

1.	Necrosis 11/01/2003 - "N-Phenylanthranilic acid (NPAA) causes renal papillary necrosis (RPN) in the rat following repeated oral dosing. " 09/01/1989 - "N-phenylanthranilic acid (N-PAA; 4 mmol/kg/day p.o.) causes a diffuse renal papillary necrosis and a polyuria in 7 days. " 06/01/2012 - "N-phenylanthranilic acid is a chloride channel blocker that causes renal papillary necrosis in rats. " 09/15/1984 - "The effect of N-phenylanthranilic acid-induced renal papillary necrosis on urinary acidification and renal electrolyte handling." 09/15/1984 - "The oral administration of a suspension of N-phenylanthranilic acid (N-PAA), over the range of 0.5 to 2 mmol/kg for 14 consecutive days, caused a dose-related renal papillary necrosis (RPN), which involved no more than 30% of the medullary apex. "
2.	Pituitary Neoplasms (Pituitary Adenoma) 04/01/1991 - "In past studies we observed that the chloride channel blocker, diphenylamine-2-carboxylate (DPC) and chemically related drugs (Hoechst compounds 131, 143, 144) inhibited cAMP formation in mouse pituitary tumor cells. "
3.	Autosomal Dominant Polycystic Kidney (ADPKD) 09/01/1995 - "Apical application of the Cl- channel blocker, diphenylamine-2-carboxylate, also inhibited fluid secretion by ADPKD monolayers (0.65 +/- 0.03 to 0.27 +/- 0.02 microliter.cm-2.h-1).(ABSTRACT TRUNCATED AT 250 WORDS)"
4.	Wounds and Injuries (Trauma) 01/07/2013 - "Comparative analysis of gene expression profiles revealed that some genes were commonly upregulated or downregulated in the renal papilla, reflecting papillary injuries induced by 2-bromoethylamine hydrobromide, phenylbutazone, or n-phenylanthranilic acid. "
5.	Starvation 10/01/1993 - "3. In the distal colon, starvation induced a large increase in the basal Isc that was unaffected by mucosal amiloride but was inhibited by tetrodotoxin (TTX) and by diphenylamine-2-carboxylic acid (DPC) unlike the fed basal Isc. "

Related Drugs and Biologics

1.	Chloride Channels (Chloride Channel)
2.	Mefenamic Acid (Pontal)
3.	Lipids
4.	Amiloride (Midamor)
5.	Acids
6.	L-Selectin
7.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
8.	Uronic Acids
9.	Tetrodotoxin (Tetradotoxin)
10.	Suspensions

Related Therapies and Procedures

1.	Oral Administration