2,3-dihydro-1H-imidazo(1,2-b)pyrazole (IMPY)

05/01/2012 - "Amyloid plaque imaging from IMPY/SPECT to AV-45/PET."
10/29/2004 - "[(125)I]IMPY and [(3)H]SB-13 show an abundant binding capacity with high binding affinities for amyloid plaques in affected cortical regions of AD brains. "
01/01/2003 - "Probes like IMPY and MIPA display high brain uptakes and fast washout in normal mice, resulting in low background signals (presumably no amyloid plaques present in normal mouse brain), whereas TZDM shows long brain retention in normal mice suggesting high nonspecific in vivo binding. "
03/01/2015 - "The specificity of this mapping was attested in mice using Thioflavin S and IMPY as positive controls of amyloid deposits. "
10/29/2004 - "The location and density of specific signal detected by [(125)I]IMPY or [(3)H]SB-13 correlated with the distribution of amyloid plaques in these brain specimens, as confirmed by thioflavin-S staining. "

01/16/2003 - "Taken together, the data suggests that [123I]16(IMPY) may be useful for imaging A beta aggregates in patients with Alzheimer's disease."
07/01/2009 - "6-[(124)I]iodo-2-(4'-N,N-dimethylamino)-phenylimidazo[1,2-a]pyridine ([(124)I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. "
07/01/2009 - "The synthesis and characterization of [(124)I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease."
01/01/2009 - "Acute toxicity of two Alzheimer's disease radiopharmaceuticals: FDDNP and IMPY."
02/01/2008 - "A potential single-photon emission computed tomography imaging agent for labeling of A beta plaques of Alzheimer's disease, IMPY (2-(4'-dimethylaminophenyl)-6-iodo-imidazo[1,2-a]pyridine), would be effective in detection of prion amyloid deposits in transmissible spongiform encephalopathies (TSEs). "

02/01/1980 - "Clearance of IMPY is impaired in the presence of hepatic insufficiency. "

02/01/2008 - "A potential single-photon emission computed tomography imaging agent for labeling of A beta plaques of Alzheimer's disease, IMPY (2-(4'-dimethylaminophenyl)-6-iodo-imidazo[1,2-a]pyridine), would be effective in detection of prion amyloid deposits in transmissible spongiform encephalopathies (TSEs). "

02/01/2008 - "In vitro autoradiographic studies were carried out with [125 I]IMPY on brain sections from scrapie-infected mice and age-matched controls. "
12/01/2010 - "Chronological studies using in vitro autoradiography were carried out with [(3)H]-PK11195 and [(125)I]-IMPY on frozen cerebral sections from scrapie-infected mice and controls. "
12/01/2010 - "These findings indicate the ability of [(125)I]-IMPY and [(125)I]-CLINDE to evaluate prion deposits and microglial activation in vitro and ex vivo in scrapie-infected mice at different stages of the disease."
02/01/2008 - "These findings indicate that IMPY can detect the prion deposits in vitro in scrapie-infected mice. "
02/01/2008 - "IMPY, a potential beta-amyloid imaging probe for detection of prion deposits in scrapie-infected mice."