caroverine (P-201)

01/01/2020 - "In this study, nano-sized carriers were formulated for improving the non- invasive oto-topical delivery of caroverine for the treatment of tinnitus. "
11/01/1997 - "In total, 60 patients with inner ear tinnitus of assumed cochlear-synaptic pathophysiology were included in the study: after computerized randomization, 30 were treated with caroverine and 30 with placebo. "
11/01/2019 - "A single dose infusion of caroverine immediately improves tinnitus grading and matching and provides immediate relief in reducing severity of tinnitus in 54.54% cases but improvement was not sustained in caroverine group at 3 month and 6 month follow-up after infusion. "
01/01/2005 - "In a representative patient cohort, the probability of a long-lasting tinnitolytic effect of lipophilic eardrops containing 1% Caroverine as their active ingredient gained in significance, crossing from low-intensity levels to high-intensity levels of individual tinnitus sensations. "
07/01/1998 - "Caroverine in tinnitus treatment."

02/01/1996 - "5. Caroverine attenuated this hypoxia-induced vigilance decrement in a dose- and time-dependent manner 6-8 h after 80 mg and 2-8 h after 120 mg. 6. Hypoxic hypoxidosis induced a deterioration of memory and attention variability, which was mitigated by 80 and 120 mg caroverine. "
02/01/1996 - "On the cerebro-protective effects of caroverine, a calcium-channel blocker and antiglutamatergic drug: double-blind, placebo-controlled, EEG mapping and psychometric studies under hypoxia."

01/01/1987 - "We present a randomized double-blind study on the efficacy of caroverine in the treatment of alcohol withdrawal symptoms. "
10/02/2003 - "Comparable to the anti-craving compound acamprosate, caroverine reduces alcohol withdrawal symptoms by an antagonism at ionotropic glutamate receptors and a blockade of calcium channels. "

12/01/2002 - "These results indicate that caroverine appears to be effective for the treatment of non-conductive smell disorders."
12/01/2002 - "The quinoxaline derivative caroverine in the treatment of sensorineural smell disorders: a proof-of-concept study."

12/01/2006 - "Physiological and morphological assessments indicated that low-dose and long-term caroverine delivery might be a new approach to protect against impulse noise-induced hearing loss. "
12/01/2006 - "Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat."
11/01/2004 - "Caroverine was found to offer significant protection of the cochlear function against noise-induced hearing loss."
01/01/2003 - "The findings suggest that local application of caroverine on the RWM for the treatment of excitotoxicity-related inner ear diseases, such as tinnitus and noise-induced hearing loss, might be both safe and more efficacious while avoiding high blood and CSF caroverine levels seen with systemic administration."
03/01/1995 - "Magnesium and the quinoxaline derivative Caroverine, which have already been tested in humans, exhibit a statistically significant otoneuroprotective action in noise-induced hearing loss and tinnitus. "